CLEC4M

(redirected from L-SIGN)

CLEC4M

A gene on chromosome 19p13 that encodes a pathogen-recognition receptor expressed on the surface of immature dendritic cells which is involved in initiating a primary immune response. The receptors are thought to recognise high-mannose N-linked oligosaccharides present on the surface of pathogens (such as HIV-1, HIV-2 and SIV gp120, among others) in a calcium-dependent fashion. Once bound, the receptor mediates endocytosis of the pathogens, which are subsequently degraded in lysosomal compartments. The receptor then returns to the cell membrane surface, and the pathogen-derived antigens are presented to resting T cells via MHC class-II proteins to initiate the adaptive immune response.
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References in periodicals archive ?
LSECtin (liver and lymph node sinusoidal endothelial cell C-type lectin, Clec4G) is a type-II transmembrane Ctype lectin protein, similar to the related proteins DC-SIGN and L-SIGN and is expressed in liver, lymph node cells, and sinusoidal endothelial cells but not monocyte derived DCs (Table 1).
MGL is highly expressed on macrophages and immature DCs, whose ligand specificity differs from DC-SIGN and L-SIGN, in that it binds to galactose and N-acetylgalactosamine leading to Th2 skewed immunity [126, 127].
Delgado, "C-type lectins DC-SIGN and L-SIGN mediate cellular entry by Ebola Virus in cis and in trans," Journal of Virology, vol.
de Lacroix de Lavalette et al., "DC-SIGN and L-SIGN are high affinity binding receptors for hepatitis C virus glycoprotein E2," Journal of Biological Chemistry, vol.
Renshaw et al., "Internalizing antibodies to the C-type lectins, L-SIGN and DC-SIGN, inhibit viral glycoprotein binding and deliver antigen to human dendritic cells for the induction of T cell responses," Journal of Immunology, vol.