Kveim reaction

Kveim reaction

Etymology: Morton A. Kveim, Norwegian physician, b. 1892; L, re, again, agere, to act
a reaction, used in a diagnostic test for sarcoidosis, to an intradermal injection of antigen derived from a lymph node known to be sarcoid. If a noncaseating granuloma appears on the skin at the test site in 4 to 8 weeks, the reaction is said to be positive evidence that the patient has sarcoidosis.
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In order to confirm the diagnosis, some additional laboratory and instrumental exams (Purified Protein Derivative (PPD) skin test; serum level of erythrocyte sedimentation rate (ESR), C-reactive protein (PCR), Calcium, Phosphate; Kveim reaction test; complete microbiologic tests, Holter monitoring, echocardiography and thallium or gallium scans, magnetic resonance imaging (MRI), CT scans of the central nervous system and myocardial involvement can be helpful [4].