KCNQ1

(redirected from Kv7.1)

KCNQ1

A gene on chromosome 11p15.5 that encodes a voltage-gated potassium channel required for the repolarisation phase of the cardiac action potential. The KCNQ1 gene product can form heteromultimers with two other potassium channel proteins, KCNE1 and KCNE3.
 
Molecular pathology
KCNQ1 mutations are associated with hereditary long QT syndrome/Romano-Ward syndrome, Jervell and Lange-Nielsen syndrome and familial atrial fibrillation.
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References in periodicals archive ?
Enhancing the predictive power of mutations in the C-terminus of the KCNQ1-encoded Kv7.1 voltage-gated potassium channel.
Variants in the 3" untranslated region of the KCNQ1-encoded Kv7.1 potassium channel modify disease severity in patients with type 1 long QT syndrome in an allele-specific manner.
Although inhibition of the hERG channel (human ether-a-go-go-related gene) regulating the major repolarizing current in the heart, IKr (delayed inward potassium current), is the most common mechanism of QT prolongation [4, 5], it can also be caused by the drug triggered inhibition of other channels, that is, potassium (Kv7.1), sodium (Nav1.5), or calcium (Cav1.2) [6-9].