KCND3

(redirected from Kv4.3)

KCND3

A gene on chromosome 1p13.3 that encodes a member of the voltage-gated, shal-related subfamily of potassium channels, which form voltage-activated A-type ion channels and are involved in the repolarisation phase of action potentials.
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References in periodicals archive ?
Effects on cloned Kv4.3 channels and native transient outward current.
Methods: Uterine tissue samples from 22 patients (cases) with histologically confirmed AM and 12 (controls) with cervical intraepithelial neoplasia were collected for both immunohistochemistry and real-time polymerase chain reaction to detect the expression of large conductance calcium- and voltage-sensitive K [sup]+ channel (BKCa)-a/[sz] subunits, voltage-gated potassium channel (Kv) 4.2, and Kv4.3. Student's t-test was used to compare the expression.
[sup][4] Here, we aimed to measure the expression levels of the BKCa-a and -[sz] subunits, Kv4.2, and Kv4.3 in MSCMs from women with AM to explore the pathogenesis of AM with the aim of developing new therapies to prevent or treat it.
Serial 4-mm sections were immunostained for BKCa-a, BKCa-[sz], Kv4.2, and Kv4.3 using standard techniques.
BKCa-[sz] (1:300 v/v) Kv4.2 (1:300 v/v) or Kv4.3 (1:200 v/v), all diluted in phosphate-buffered saline (PBS).
Detection of BKCa-a, BKCa-[sz], kv4.2, and kv4.3 in uterine tissues with and without adenomyosis
Casis, "Differential modulation of Kv4.2 and Kv4.3 channels by calmodulin-dependent protein kinase II in rat cardiac myocytes," American Journal of Physiology--Heart and Circulatory Physiology, vol.
Reihill et al., "Regulation of Kv4.3 currents by [Ca.sup.2+]/calmodulin-dependent protein kinase II," American Journal of Physiology--Cell Physiology, vol.
Women showed particularly lower atrial expression levels of several important genes encoding for potassium channels, including Kv4.3, KChIP2, Kv1.5 and Kir3.1.
More recently, it was reported that chronic hypoxia also decreases the mRNA expression of Kv1.1, Kv1.5, Kv2.1, KV4.3, and Kv9.3 a subunits in cultured rat PASMCs [20, 25].
Remodeling of Kv4.3 potassium channel gene expression under the control of sex hormones.
reported that electrical stimulation of hESC-derived cardiomyocytes at 1 Hz increased expression of cardiac-specific genes (such as SCN5A, MLC2V, and Kv4.3), and a higher percentage of cardiomyocytes showed longer action potential duration, but electrical stimulation did not affect resting membrane potential or action potential upstroke velocity [41].