Hydrogen sulfide targets the cys320/cys529 motif in kv4.2
to inhibit the ito potassium channels in cardiomyocytes and regularizes fatal arrhythmia in myocardial infarction.
Toyama, "Regulation of Kv4.2
and Kv1.4 [K.sup.+] channel expression by myocardial hypertrophic factors in cultured newborn rat ventricular cells," Journal of Molecular and Cellular Cardiology, vol.
The effects on E-LTP may be ascribed to ERK regulation of the Kv4.2
channel, which leads to a reduction in its conductance properties, and in turn, an increase in hippocampal cellular excitability [147, 148].
Similarly, estrogen can exert rapid regulation of potassium and calcium channels in neurons by activation of estrogen receptors to regulate the neuronal activities  and inhibit the epileptiform bursting activities in cultured hippocampal neurons by activation of the voltage-gated potassium channel Kv4.2
Results: The BKCa-a/[sz] subunits, Kv4.2
, and Kv4.3 were located in smooth muscle cells, glandular epithelium, and stromal cells.
Casis, "Differential modulation of Kv4.2
and Kv4.3 channels by calmodulin-dependent protein kinase II in rat cardiac myocytes," American Journal of Physiology--Heart and Circulatory Physiology, vol.
Our precious data clearly demonstrated that the decreased [I.sub.to] in ischemic hearts was associated with functional impairment and down-regulation of expression of Kv4.2
(Zhang et al.
One of these ion channels is potassium channel protein, Kv4.2
concentration decreases through myocardium, from epicardium with high Kv4.2
to endocardium with low Kv4.2
, also known as Kcnd2, is the most abundant member of the Kv4 family of Kva subunits and encodes [I.sub.tol] in rats.
DETERMINING NEURONAL INTERLEUKIN-16 AND KV4.2
INTERACTION AND REDUCING NEURONAL INTERLEUKIN-16 VIA SMALL INTERFERING RNA.
Buckingham et al., "Tau-dependent Kv4.2
depletion and dendritic hyperexcitability in a mouse model of Alzheimer's disease," The Journal of Neuroscience, vol.
Ding et al., "Hydrogen sulfide targets the Cys320/Cys529 motif in Kv4.2
to inhibit the 7to potassium channels in cardiomyocytes and regularizes fatal arrhythmia in myocardial infarction," Antioxidants & Redox Signaling, vol.