KCNH3

(redirected from Kv12.2)

KCNH3

A gene on chromosome 12q13 that encodes an alpha subunit of a voltage-gated, potassium channel subfamily H, which elicits an outward current with fast inactivation.
Segen's Medical Dictionary. © 2012 Farlex, Inc. All rights reserved.
References in periodicals archive ?
Jegla's team focused on a particular potassium-channel gene -- called Kv12.2 -- that is active in resting nerve cells and is expressed in brain regions prone to seizure."We decided that Kv12.2 was a good candidate for study because it is part of an old gene family that has been conserved throughout animal evolution," Jegla said.
Jegla's team focused on a particular potassium-channel gene - called Kv12.2 - that is active in resting nerve cells and is expressed in brain regions prone to seizure.
Jegla said: "We decided that Kv12.2 was a good candidate for study because it is part of an old gene family that has been conserved throughout animal evolution.
Previous studies have suggested that the Kv12.2 potassium channel has a role in spatial memory, but Jegla and his team focused on how it might be related to seizure disorders.
They found that mice missing the Kv12.2 gene did indeed have frequent seizures, albeit without convulsions.
Jegla said: "In mice without a functioning Kv12.2 gene, nerve cells had abnormally low firing thresholds.