KCNH1

(redirected from Kv10.1)

KCNH1

A gene on chromosome 1q32.2 that encodes a pore-forming alpha subunit of the voltage-gated, potassium channel subfamily H, which is part of a non-inactivating delayed rectifier potassium channel. It is activated in the embryo with myoblast differentiation; it is highly expressed in brain and in myoblasts.

Molecular pathology
KCNH1 is overexpressed in some cancers.
References in periodicals archive ?
The voltage-dependent potassium channel Kv10.1 and cancer
melanogaster llamada Ether a-go-go (debido a sus movimientos rtmicos al ser anestesiada con ter), se logro identificar otro canal de potasio dependiente de voltaje con propiedades inusuales con el cual se formo una nueva familia llamada eag (de Ether-a-go-go) y que en la nomenclatura oficial se conoce como Kv10.1. La "K" indica que el canal es selectivo para potasio, la "v" que es dependiente de voltaje, y el numero "10.1", que pertenece a la dcima familia encontrada y es su primer miembro descrito.
Sorprendentemente, el Kv10.1 es permeable al cesio.
La gran dependencia de la cintica de activacion del potencial anterior es una propiedad tan peculiar que permite determinar y aislar las corrientes del Kv10.1 de cualquier preparacion que contenga muchos otros canales dependientes de voltaje.
?Cual es la posible funcion fisiologica del Kv10.1?
Ya que la ausencia del Kv10.1 parece no causar trastornos graves ni durante la embriognesis ni en el adulto, aparte de la modulacion de la excitabilidad, ?cuales son sus otras funciones fisiologicas o fisiopatologicas?
So far, two EAG isoforms Eag1 (KCNH1, Kv10.1) and Eag2 (KCNH5, Kv10.2) have been identified and they show similar electrophysiological features such as slow voltage-dependent activation, noninactivating, and inhibition by intracellular [Ca.sup.2+] [[[Ca.sup.2+]].sub.i] [4, 6, 7].
E65 causes an overall reduction in KV10.1 protein level and also reduces single channel current, whereas E70 mainly affected the glycosylation pattern but without detectably affecting the electrophysiological parameters [13].
Pardo, "Kv10.1 [K.sup.+] channel: from physiology to cancer," Pflugers Archiv European Journal of Physiology, vol.
Alves, "In vivo imaging of tumour xenografts with an antibody targeting the potassium channel Kv10.1," European Biophysics Journal, vol.
Sanchez et al., "Alternatively spliced isoforms of Kv10.1 potassium channels modulate channel properties and can activate cyclin-dependent kinase in Xenopus oocytes," The Journal of Biological Chemistry, vol.
Farsi et al., "Kv10.1 opposes activity-dependent increase in [Ca.sup.2+] influx into the presynaptic terminal of the parallel fibre-Purkinje cell synapse," Journal of Physiology, vol.