The sieve's place in the treatment of septic shock syndrome (due to TNF alpha and other inflammatory cytokines) from endotoxin activation of the reticulo-endothelial system, especially the liver macrophages (Kuppfer cells
) being negated by infusion of chylomicrons (21).
Facilitate the removal of immune complexes especially by the spleen and Kuppfer cells
so that the liver sequesters junk rather than presenting it to T cells.
In the liver resident macrophages, known as Kuppfer cells
, play a major role in filtering pathogens and toxins from circulation.
The bulk of the liver is primarily composed of parenchymal cells such as hepatocytes, hepatocyte precursor cells (oval cells or Ito cells), stellate cells, kuppfer cells
, epithelial cells, sinusoidal epithelial cells, biliary epithelial cells and fibroblasts (7).
These patients also had iron deposition in hepatocytes and Kuppfer cells
. Saven and Beutler (1989) showed iron overload was present in a patient who had received 52 g of elemental iron intramuscularly over a 20-year period.
Others have also reported that genetic deletion of Ppar[beta]/[delta] in mice impaired the alternative anti-inflammatory M2 activation of hepatic macrophages (Kuppfer cells
In some areas, the sinusoids were congested and the Kuppfer cells
were hipertrofied and hiperplasic.