Su, "Lipopolysaccharides in liver injury: molecular mechanisms of Kupffer cell
activation," American Journal of Physiology-Gastrointestinal and Liver Physiology, vol.
Monocyte-derived (freshly infiltrating) macrophages are characterized as CD11b+ F4/80+ cells by FACS in mice, whereas matured monocyte-derived and resident Kupffer cells
are [CD11b.sup.lo] F4/[80.sup.hi] .
Tiegs, "IL-10, regulatory T cells, and Kupffer cells
mediate tolerance in concanavalin A-induced liver injury in mice," Hepatology, vol.
are very good sources of mitogenic cytokines such as TNFa.
The rate of Kupffer cells
in liver and ATM infiltration into adipose tissue was also decreased in the Euphorbia-treated group.
Fixed monocytes (Kupffer cells
) were present in the lining of sinusoids (Fig.1).
Microscopically, hepatocytes were showed minimal degeneration, sinusoidal congestion and moderate multifocal aggregations of golden yellow coloured pigment in kupffer cells
Besides DCs, intrahepatic Kupffer cells
also participate in the anti-HBV immune response, partly through interfering with the NK cells.
Histoplasmosis features portal lymphohistiocytic inflammation and sinusoidal Kupffer cell
hyperplasia, and organisms are generally present within both portal macrophages and Kupffer cells
(Figure 8, A and B).35 Discrete granulomas and giant cells are seen in only a minority of cases.
Examples include Kupffer cells
, macrophages residing in the liver, and microglia, residing in the central nervous system.
These changes were accompanied by swelling of Kupffer cells
in congested sinusoidal ves-sels.16 The determination of transaminase activity in serum is a common means of detecting liver damage.
(2007) reported that a high-fat diet induced PS externalization on erythrocytes and erythrophagocytosis by Kupffer cells
in the liver, resulting in inflammation and hepatic fibrosis.