The role of
kupffer cells in carbon tetrachloride intoxication in mice.
These findings suggest that the phagocytic ability of
Kupffer cells is reduced in fat-containing cells compared with normal liver cells.
Morphometric Observations: The details of Numerical density of
Kupffer cells on the area (Nak) are summarized in Table 1.
Numerical density of
Kupffer cells on the area (Nak)--It expresses the number of
Kupffer cells per unit area (per [cm.sup.2]).
The body responds to this increase in endotoxin levels by launching a coordinated immune response, marked by activation of immune cells residing in the liver (i.e.,
Kupffer cells).
Lanthier, "Targeting
Kupffer cells in non-alcoholic fatty liver disease/non-alcoholic steatohepatitis: why and how?" World Journal of Hepatology, vol.
Liver macrophages consist of ontogenically distinct populations, namely, the resident
Kupffer cells (KCs) and monocyte-derived macrophages (Mo-Mfs).
Thomas, "Surface expression of heterogeneous nuclear RNA binding protein M4 on
Kupffer cell relates to its function as a carcinoembryonic antigen receptor," Experimental Cell Research, vol.
Tokar et al., "Leptin is key to peroxynitrite-mediated oxidative stress and
Kupffer cell activation in experimental non-alcoholic steatohepatitis," Journal of Hepatology, vol.
The mice were sacrificed, liver tissues were collected and stained with HE (a), and
Kupffer cell activation was indicated by the F4/80 IHC (b).
Small
Kupffer cell clusters and, rarely, discrete noncaseating granulomas or fibrin-ring granulomas, may be seen in Epstein-Barr virus infection of the liver.
Receptors located on resident immune cells in the liver (i.e.,
Kupffer cells; see sidebar, "Liver Cell Types and Their Roles in ALD") sense and transmit these immune challenges.
