Scattered neuroendocrine cells interspersed among basal cells (reminiscent of bronchial Kulchitsky cells
) have been reported within the tumor.
It originates from carcinoid neuroendocrine cells (Kulchitsky cells
) usually present in the thymus gland .
Carcinoid tumours arise from the neuroendocrine cells of the bronchial epithelium known as Kulchitsky cells
and comprise 4% of all lung malignancies.
(9) Contrary to the early theory of derivation from Kulchitsky cells
, it is now believed that SCC of the bladder originates from the totipotent stem cells present in the submucosa of the bladder wall.
(1) Derived from Kulchitsky cells
, these tumors can arise anywhere along the gastrointestinal tract or bronchial mucosa.
The normal neuroendocrine (NE) cells in the lung (known as Kulchitsky cells
) are present as rare single cells or small cell clusters of 4 to 10 cells (known as neuroepithelial bodies) within bronchial and bronchiolar epithelium.