KLF6

(redirected from Kruppel-like factor 6)

KLF6

A gene on chromosome 10p15 that encodes a zinc finger protein belonging to the Kruppel-like family of transcription factors; it activates transcription, acting as a tumour suppressor.

Molecular pathology
Some KLF6 transcription variants have been linked to carcinogenesis.
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References in periodicals archive ?
Many other SNPs of different genes involved in lipid metabolism, such as lipin 1 (LPIN1), oxidative stress, such as superoxide dismutase 2 (SOD2), and fibrogenesis, such as Kruppel-like factor 6 (KLF6), have been associated with the severity of liver damage in different studies on NAFLD patients [8-12].
Vetter et al., "Glucokinase links Kruppel-like factor 6 to the regulation of hepatic insulin sensitivity in nonalcoholic fatty liver disease," Hepatology, vol.
(+) p < 0.05 and (++) p < 0.001 versus healthy subjects; * p < 0.01 and ** p < 0.001 versus noncirrhotic NAFLD; NAFLD: nonalcoholic fatty liver disease; NASH: nonalcoholic steatohepatitis; BMI: body mass index; T2DM: type 2 diabetes mellitus; PNPLA3: patatin-like phospholipase domain containing protein 3; TM6SF2: transmembrane 6 superfamily member 2; KLF6: Kruppel-like factor 6; SOD2: superoxide dismutase 2; LPIN1: lipin 1.
On the other hand, Kruppel-like factor 6 is a coactivator of NF-[kappa]B that mediates p65-dependent transcription of selected downstream genes [27].
Aberrant expression of kruppel-like factor 6 protein in colorectal cancers.
Kruppel-like factor 6 regulates mitochondrial function in the kidney.
Transcription factors Kruppel-like factor 6 and peroxisome proliferator-activated receptor-{gamma} mediate high glucose-induced thioredoxin-interacting protein.
Elferink, "The tumor suppressor kruppel-like factor 6 is a novel aryl hydrocarbon receptor DNA binding partner," Journal of Pharmacology and Experimental Therapeutics, vol.
Madam, Kruppel-like factor 6 (KLF6) is a zinc finger transcription factor that induces apoptosis in cancer cells leading to suppression of tumour growth.
De Graeve et al., "Kruppel-like factor 6 (KLF6) affects the promoter activity of the [alpha]1-proteinase inhibitor gene," Investigative Ophthalmology & Visual Science, vol.