KLF5

(redirected from Kruppel-like factor 5)

KLF5

A gene on chromosome 13q22.1 that encodes a protein of the Krüppel-like factor subfamily of zinc finger proteins; it localises to the nucleus, binds to GC box promoter elements and is thought to activate transcription of GC box genes.
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References in periodicals archive ?
Kruppel-like factor 5 (KLF5) belongs to the family of Kruppel-like transcription factors, of which 17 members have been identified to date.
Ghaleb et al., "Kruppel-like factor 5 mediates cellular transformation during oncogenic KRAS-induced intestinal tumorigenesis," Gastroenterology, vol.
and Kruppel-like factor 5. Diencephalon/mesencephalon homeobox protein 1-B came on very early at 90 min, with a 2.69 log2 fold change (log2FC); and Homeobox vent 1, Kruppel-like factor 7, and Kruppel-like factor 5 had high log2FC later, at the 150-300-min time points (Fig.
While the developmental transcription factors (Diencephalon/mesencephalon homeobox protein 1-B, Homeobox vent 1, Kruppel-like factor 7 and Kruppel-like factor 5) were differentially expressed earliest in the experiment, the stress transcription factors (Elk-3, NF-[kappa]B, FOSB, and AP-1) were expressed between 150-300 min.
McConnell et al., "Kruppel-like factor 5 is an important mediator for lipopolysaccharide-induced proinflammatory response in intestinal epithelial cells," Nucleic Acids Research, vol.