KLF4

(redirected from Kruppel-like factor 4)

KLF4

A gene on chromosome 9q31 that encodes a protein of the Krüppel-like family of transcription factors that can act as an activator and repressor. KLF4 binds to its own promoter region and activates self-transcription; it regulates expression of key transcription factors during embryonic development and plays an important role in keeping embryonic stem cells in stasis, preventing their differentiation. KLF4 is required for the barrier function of the skin and the ocular surface. It is involved in epithelial cell differentiation and may play a role in skeletal and kidney development. KLF4 contributes to downregulating p53/TP53 transcription.
Segen's Medical Dictionary. © 2012 Farlex, Inc. All rights reserved.
References in periodicals archive ?
Kruppel-like factor 4 (KLF4) can also be referred to as gut-enriched KLF (GKLF) or epithelial zinc finger protein (EZF) which mainly expresses in epithelial tissues of the mammals, including the intestine, skin, thymus, and lung.
Search terms represented as follows: (KLF4 OR Kruppel-like factor 4 OR Gut-enriched KLF OR GKLF OR ZEF OR Epithelial Zinc Finger Protein) AND (cancer OR tumor OR neoplasm OR carcinoma) AND (Prognosis OR prognostic OR survival OR outcome).
Hayashi, "Deletion of Kruppel-like factor 4 in endothelial and hematopoietic cells enhances neointimal formation following vascular injury," Journal of the American Heart Association, vol.
Three target genes of miR-34c (zinc finger protein 148: ZNF148, kruppel-like factor 4: KLF4, and platelet-derived growth factor receptor alpha: PDGFRA) were predicted by four kinds of bioinformatics software (microRNA.org, miRDB, miRGen, TargetScan).
Identification of Kruppel-like factor 4 as a potential tumor suppressor gene in colorectal cancer.
The gut-enriched Kruppel-like factor (Kruppel-like factor 4) mediates the transactivation effect of p53 on the p21 wA.rvap, promoter.
In addition to RORC, KrUppel-like factor 4 (KLF4), a transcription factor of cell differentiation, tumor suppression, stem cell properties, and malignant transformation, is another positive regulator of Th17 differentiation [19-21].
Rosenzweig et al., "Cutting edge: the transcription factor Kruppel-like factor 4 regulates the differentiation of Th17 cells independently of RORyt," Journal of Immunology, vol.
Jain, "Kruppel-like factor 4 is a mediator of proinflammatory signaling in macrophages," Journal of Biological Chemistry, vol.
Search terms represented as follows: (KLF4 OR Kruppel-like factor 4 OR Gutenriched KLF OR GKLF OR ZEF OR Epithelial Zinc Finger Protein) AND (cancer OR tumor OR neoplasm OR carcinoma) AND (Prognosis OR prognostic OR survival OR outcome).
TGF-[beta]1 Downregulates Kruppel-Like Factor 4 in Mouse Lung Epithelial LA-4 Cells.
Wang et al., "Kruppel-like factor 4 represses transcription of the survivin gene in esophageal cancer cell lines," Biological Chemistry, vol.