KLF2

(redirected from Kruppel-like factor 2)

KLF2

A gene on chromosome 19p13.11 that encodes a member of the Kruppel-like family of broadly expressed zinc finger transcription factors, which regulates T-cell trafficking by promoting expression of the lipid-binding receptor S1P1 (S1PR1) and the selectin CD62L.
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References in periodicals archive ?
Kruppel-like factor 2 (KLF2) is a laminar flow inducible transcription factor primarily expressed by the endothelial cell and plays an important role in the regulation of endothelial function [6-8].
Jain, ""Go with the flow": how Kruppel-like factor 2 regulates the vasoprotective effects of shear stress," Antioxidants & Redox Signaling, vol.
Dai et al., "Integration of flow-dependent endothelial phenotypes by Kruppel-like factor 2," The Journal of Clinical Investigation, vol.
Kruppel-like factor 2 (KLF2), a member of the Kruppel-like factor family of zinc finger transcription factors, may exert anti-inflammatory activity through ATF2 inhibition in the nucleus [89].
Uttridge et al., "Chronic exposure to laminar shear stress induces Kruppel-like factor 2 in glomerular endothelial cells and modulates interactions with co-cultured podocytes,"
In this regard, ongoing work evaluating statin effects on the biosynthesis of isoprenoids and on the induction of nuclear factors such as Kruppel-like factor 2 has provided initial clues that need to be pursued aggressively in basic laboratory settings.