Kruppel-like factor 2 (KLF2) is a laminar flow inducible transcription factor primarily expressed by the endothelial cell and plays an important role in the regulation of endothelial function [6-8].
Jain, ""Go with the flow": how Kruppel-like factor 2 regulates the vasoprotective effects of shear stress," Antioxidants & Redox Signaling, vol.
Dai et al., "Integration of flow-dependent endothelial phenotypes by Kruppel-like factor 2," The Journal of Clinical Investigation, vol.
Kruppel-like factor 2
(KLF2), a member of the Kruppel-like factor family of zinc finger transcription factors, may exert anti-inflammatory activity through ATF2 inhibition in the nucleus .
Uttridge et al., "Chronic exposure to laminar shear stress induces Kruppel-like factor 2
in glomerular endothelial cells and modulates interactions with co-cultured podocytes,"
In this regard, ongoing work evaluating statin effects on the biosynthesis of isoprenoids and on the induction of nuclear factors such as Kruppel-like factor 2
has provided initial clues that need to be pursued aggressively in basic laboratory settings.