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the sequence of chemical reactions, occurring primarily in the liver, that results in the production of urea; the key reaction is the hydrolysis of l-arginine by arginase to l-ornithine and urea; l-ornithine is then converted to l-citrulline by a carbamoylation reaction, then to l-argininosuccinate by an amination reaction involving l-aspartic acid; finally, a lyase-dependent step generates arginine and fumarate.
See urea cycle.
Henseleit,K., German internist, 1907–.
Krebs-Henseleit cycle - see under Krebs, Sir Hans Adolph
Krebs,Sir Hans Adolph, German biochemist in England and Nobel laureate, 1900-1981.
Krebs cycle - together with oxidative phosphorylation, the main source of energy in the mammalian body and the end toward which carbohydrate, fat, and protein metabolism are directed. Synonym(s): tricarboxylic acid cycle
Krebs-Henseleit cycle - the sequence of chemical reactions, occurring primarily in the liver, that results in the production of urea. Synonym(s): urea cycle
Krebs-Ringer solution - a modification of Ringer solution.