Krabbe's disease


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Related to Krabbe's disease: Gaucher's disease

Krabbe's disease

 [krah´bez]
a familial form of leukoencephalopathy beginning in infancy, in which the sphingolipid ceramide galactoside accumulates in the tissues due to a deficiency of β-galactosidase, marked pathologically by cerebral demyelination and by the presence of large globoid bodies in the white substance.

Krabbe's disease

See GLOBOID CELL LEUKODYSTROPHY.
References in periodicals archive ?
Krabbe's disease is a rare and terminal genetic mutation that damages and attacks the nervous system.
Suzanne suffered from a degenerative nerve system condition called Krabbe's disease, which left her blind, unable to walk, talk and limited her ability to move.
Normal nerve function is lost in demyelinating disorders, such as MS and the rare, fatal, childhood disease, Krabbe's disease.
Fortunately, now babies with Krabbe's disease do not need to suffer the way that LeA suffered.
Globoid cell leukodystrophy, also known as Krabbe's disease, is an autosomal recessive white matter disorder caused by the deficiency of [beta]-galactocerebrosidase.