Finally, Farley &
Koshland [14] demonstrate that PD patients practicing large amplitude exercises (i.e., those involving large scale limb movements such as reaching an object, walking, twisting the torso to the side, stepping and reaching forward or sideways) reap measurable benefits in terms of improvements in speed and agility for both upper and lower limbs.
Koshland Jr, "Active site water molecules revealed in the 2.1 A resolution structure of a site-directed mutant of isocitrate dehydrogenase," Journal of Molecular Biology, vol.
The editor of Science, Daniel
Koshland, was aware of the controversy and took another look at the paper.
In five studies (Fischer and
Koshland 2007; Pearce et al.
"Instead of focusing on legacy content that is three to 10 years old, much of which sees very limited use, we will work to create new public content that includes accessible features," said Cathy
Koshland, vice chancellor for undergraduate education, in a message to the campus community.
Becky Farley and Gail
Koshland. It began as a concept of "Learning and Training BIG" based on principles first described and researched for LSVT LOUD[R], where the primary treatment focus was amplitude [5].
Galloway and
Koshland argued that most multijoint movements of the upper extremities have a shoulder-centered pattern.
Koshland Jr., "Induction and expression of long- and short-term neurosecretory potentiation in a neural cell line," Neuron, vol.
Koshland, "Stereochemistry and the mechanism of enzymatic reactions," Biological Reviews of the Cambridge Philosophical Society, vol.
He chaired the advisory panel that oversaw the design of an exhibit devoted to global warming at the National Academy's
Koshland Museum.
A good example from biochemistry is the replacement of the old "lock and key" model of enzyme specificity (Fischer, 1894) by the "induced fit" model (
Koshland, 1958).
More than 20 years ago, Daniel
Koshland compared basic with applied research, stating: "Basic research is the type that is not always practical but often leads to great discoveries.