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A type of targeted mutation in which an alteration in gene function is produced, usually a gain of function by adding or substituting genetic material.
Example Substitution of a mouse gene sequence for a human sequence
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Based on the somatic cell nuclear transfer (SCNT) cloning or direct injection technique into one-cell-stage embryos, CRISPR/Cas9-mediated knockout and knockin individuals have been successfully generated in various mammals [13,15,16].
2008): "Ultrasonic vocalization impairment of Foxp2 (R552H) knockin mice related to speech-language disorder and abnormality of Purkinje cells", Proceedings of the National Academy of Sciences, 105, pp.
25: Cruckton & District Ploughing & Hedging Society ploughing match, Hanley Hall, Knockin, Shropshire.
He just knows he doesn't want to miss the songs when they come a knockin.
The businessman, who is also Baron Strange of Knockin, Baron Hungerford, Baron de Moleyns and a co-heir to the barony of Grey de Ruthyn, has been forced to take time off his beloved polo to prevent Barclays Bank getting its hands on his pounds 3.
Knockin mice expressing fluorescent {delta}opioid receptors uncover G protein-coupled receptor dynamics in vivo.
The man responsible for classics such as Blowin' In The Wind, The Times They Are A-Changin', Lay Lady Lay, Like A Rollin' Stone and Knockin On Heaven's Door, has been hailed as one of the most important voices of his generation.
Vanessa Alexander Johnson is the author of When Death Comes a Knockin,' a detail account of her personal losses and experiences with grief.
Investigators then turned to a more subtle strategy, making what they call knockin mice.
lt;tannie90> when do you want me to call - have to be careful in case parents come in - mum always walks into my room without knockin
Michael Bennett has unearthed an extraordinary circumstance that must have clouded Audelay's subsequent life: the poet's employment in the household of the feckless Lord Richard Lestrange of Knockin (who held the title 1397-1449) caused Audelay to be involved in what Bennett terms 'the most notorious crime of sacrilege in the kingdom within living memory' (p.