knockout

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Related to Knock-out option: Barrier options, Up and Out Option

knock·out

, knock-out (nok'out, nok'-out),
A genetically engineered organism in which the genome has been altered by site-directed recombination so that a gene is deleted.

knockout

(nŏk′out′)
adj. also knock-out (nŏk′out′)
Genetics Having a specific single gene inactivated or removed by genetic manipulation: knockout mice used in an experiment.
Experimental biology A genetically engineered mutant animal—e.g., Drosophila, mouse, fish, et al—in which a targeted gene has been inactivated to facilitate analysis of the knocked-out gene’s activity and function
Molecular medicine adjective Referring to the inactivation of a specific gene or genes noun A lab organism—e.g., yeast or mouse—in which a specific gene is altered, inactivating it and creating a model for a particular disease; in knockouts, an extracellular signal is converted to a functional intracellular change
Sports medicine KO The vanquishing of an opponent in a combat sport by bringing the opponent to the mat or ground. In boxing, this is defined as when the boxer is knocked down and cannot get up by the referee’s count of 10. A technical knockout (TKO) is one in which the referee or ringside doctor determines that the fighter is unable to defend himself or has sustained a serious injury, or when the fighter’s handlers throw in the towel
Vox populi Bombshell A woman who is stunningly beautiful

knock·out

, knock-out (nok'owt)
A genetically engineered organism in which the genome has been altered by site-directed recombination so that a gene is deleted.

knockout

see GENE DISRUPTION.