Klinefelter's syndrome


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Related to Klinefelter's syndrome: Androgen insensitivity syndrome, XYY syndrome

Klinefelter's syndrome

 [klīn´fel-terz]
a condition in males characterized by small testes, with fibrosis and hyalinization of seminiferous tubules, impairment of function and clumping of Leydig cells, and an increase in urinary gonadotropins, associated with an abnormality of the sex chromosomes. It is associated typically with an XXY chromosome complement.
Klinefelter's syndrome. Redrawn from Damjanov, 2000.

Klinefelter syndrome

A syndrome with a 47, XXY chromosome complement, in which the subjects are phenotypically male but have seminiferous tubule dysgenesis, elevated plasma and urinary gonadotropins, variable gynecomastia, eunuchoid habitus and possibly female secondary sex characteristics. Some patients are chromosomal mosaics, with two or more cell lines of different chromosome constitution.

Klinefelter's syndrome

A male bodily disorder caused by one or more additional X (sex) chromosomes. Instead of the normal X and Y sex chromosomes, men with Klinefelter's syndrome have an XXY configuration. This has a feminizing effect. The penis and testicles are small and there may be female breast development and diminished sexual interest (libido). Homosexuality and transvestism are common. The diagnosis can easily be confirmed by chromosomal analysis. Hormonal and plastic surgical treatment can help. (Harry Fitch Kleinfelter, American physician, b. 1912)

Klinefelter's syndrome

a human chromosomal abnormality in which there is an extra X-chromosome making a complement of 44 autosomes plus XXY (47 in all). The affected individuals are male (showing the SEX DETERMINATION role of the Y-chromosomes) but with much reduced fertility, and a number of female secondary sexual characteristics, such as breasts, often occur. About 1 in 1000 liveborn males are affected by this condition, which arises from NONDISJUNCTION in one or other parent, more probably the female where there is a distinct positive age effect (as in DOWN'S SYNDROME).

Klinefelter's syndrome

Chromosomal abnormality characterized by small testes and male infertility.

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References in periodicals archive ?
Fenichel, "Klinefelter's syndrome and bone mineral density: is osteoporosis a constant feature?" Annales d'Endocrinologie, vol.
Hormonal studies in Klinefelter's syndrome. Clin Endocrinol (Oxf) 1975;4:399-411.
Klinefelter's syndrome (47, XXY) represents the most common karyotype abnormality in azoospermia and severe male factor infertility, followed by Y chromosome terminal deletions (Yq-) and structural autosomal abnormalities (Krausz, 2011).
For example, in a cytogenetic study on a large Dutch infertile population (1792 infertile men) as low as 72 cases (4%) with chromosomal abnormalities were reported and Klinefelter's syndrome (either pure or mosaic form) was found in just 12 patients (0.6%) (6).
One thing the jury did not know was that you were suffering from Klinefelter's Syndrome. If you go to prison today you may be picked on or bullied.
"One thing the jury did not know was that you were suffering from Klinefelter's Syndrome, and a professor has prepared a very full report which indicates why you may have gone wrong in the early stages of your treatment.
The test identified two cases of trisomy 21 and one case each of Turner's syndrome and Klinefelter's syndrome in 110 pregnancies, according to Dr.
Differential diagnosis of men with hypergonadotropic hypogonadism includes Klinefelter's syndrome, cryptorchidism, hemochromatosis, and external testicular insults including trauma, mumps, and radiation.
He had Klinefelter's syndrome, born with the genetic make-up of both sexes.
The author mentions four syndromes - Turner's syndrome, Klinefelter's syndrome, X double Y, and Triple X.
* Daily alcohol consumption, high levels of radiation exposure, high levels of estrogen, inherited gene mutation, a family history of breast cancer, men with Klinefelter's syndrome, and a disturbance in the liver's metabolization are risk factors that increase the chance of developing breast cancer.
I was diagnosed 12 years ago with Klinefelter's syndrome, which has as a symptom low testosterone ("Unproven Elixir," SN: 5/10/03, p.