Klebsiella pneumoniae carbapenemase

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Klebsiella pneumoniae carbapenemase

A plasmid-transferrable beta-lactamase (enzyme) carried by an increasing number of strains of Klebsiella pneumoniae as well as other Enterobacteriaceae. Hydrolysis of the beta-lactam ring renders many of the antibiotics—in particular, extended spectrum cephalosporins and carbapenems (imipenem, meropenem, and ertapenem)—ineffective.

References in periodicals archive ?

Overview of the epidemiology and the threat of Klebsiella pneumoniae Carbapenemases (KPC) resistance.

Risk Factors for Carbapenem-resistant Klebsiella pneumoniae Infection and Mortality of Klebsiella pneumoniae Infection

Genomic epidemiology of an endoscope-associated outbreak of Klebsiella pneumoniae carbapenemase (KPC)-producing K.

An Outbreak of Infections Caused by a Klebsiella pneumoniae ST11 Clone Coproducing Klebsiella pneumoniae Carbapenemase-2 and RmtB in a Chinese Teaching Hospital

Carbapenem-resistant Escherichia coli harboring Klebsiella pneumoniae carbapenemase (Beta) -lactamases associated with long-term care facilities.

Frequency of Class B Carbapenemases (M (Beta) L) in enterobacteriacae

Two carbapenemase subclasses are especially problematic: Klebsiella pneumoniae carbapenemase (KPC) and New Delhi metallo-[beta]-lactamase-1 (NDM-1).

KPC and NDM-1 genes in related enterobacteriaceae strains and plasmids from Pakistan and the United States

2) Production of Klebsiella pneumoniae carbapenemase (KPC) enzymes is the most common mechanism of resistance, while the incidence of zinc-dependent metallop-lactamases (VIM, IMP, and NDM types) is also increasing.

Efficacy of polymyxins in the treatment of carbapenem-resistant Enterobacteriaceae infections: a systematic review and meta-analysis

Gasink, et al found that severe illness, prior fluoroquinolone and extended- spectrum cephalosporin use are risk factors for isolation of Klebsiella pneumoniae carbapenemase (KPC)- producing K.

Risk factors for carbapenem resistant bacteraemia and mortality due to gram negative bacteraemia in a developing country

Carbapenem resistance as a result of Klebsiella pneumoniae carbapenemase (KPC; Class A), New Delhi metallo-beta-lactamase-1 (NDM-1; Class B) and OXAsubtypes (Class D) are thought to occur at low levels in Africa.

NDM-1 imported from India - first reported case in South Africa

However, the most common mechanism of carbapenem resistance among Enterobacteriaceae in the United States remains the production of the Klebsiella pneumoniae carbapenemase (KPC).

Update: detection of a verona integron-encoded metallo-beta-lactamase in klebsiella pneumoniae - United States, 2010

Currently, the main acquired carbapenemases around the world are Klebsiella pneumoniae carbapenemase (KPC), oxacillinase-48 (OXA-48), and NDM.

Response to detection of New Delhi metallo-[beta]-lactamase-producing bacteria, Brazil

Retrospective clinical data suggest that antibiotic combinations, including tigecycline (TIG) and polymyxin (POL), result in better outcomes than monotherapy against Klebsiella pneumoniae carbapenemase (KPC)-producing K.

Efficacy of tigecycline, polymyxin, gentamicin, meropenem and associations in experimental Klebsiella pneumoniae carbapenemase-producing Klebsiella pneumoniae non-lethal sepsis

Until recently Klebsiella pneumoniae carbapenemase (KPC) first detected in Klebsiella pneumoniae (molecular Class A enzyme), and Verona integron-encoded metallo-b- lactamase ( VIM) carbapenemase (molecular Class B enzyme) were considered to be the most frequent types of carbapenemases reported from countries including United States, Israel, Turkey, China, India, the United Kingdom, Greece and Nordic countries.

Effectiveness of Modified Hodge Test to detect NDM-1 Carbapenemases: an experience from Pakistan

CRE infections in the United States are often mediated by acquisition of Klebsiella pneumoniae carbapenemase (KPC) expressed by Klebsiella spp.

Carbapenem-resistant Enterobacter cloacae isolates producing KPC-3, North Dakota, USA