Klebsiella pneumoniae carbapenemase


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Klebsiella pneumoniae carbapenemase

A plasmid-transferrable beta-lactamase (enzyme) carried by an increasing number of strains of Klebsiella pneumoniae as well as other Enterobacteriaceae. Hydrolysis of the beta-lactam ring renders many of the antibiotics—in particular, extended spectrum cephalosporins and carbapenems (imipenem, meropenem, and ertapenem)—ineffective.
References in periodicals archive ?
* Klebsiella pneumoniae carbapenemase (KPC), New Delhi metallo-beta-lactamase (NDM), Verona integron-mediated metallo-[beta]-lactamase (VIM), imipenemase (IMP), and oxacillinase-48-like carbapenemase (OXA-48).
Domestically Acquired Verona Integron-Mediated Metallo-[beta]-Lactamase-Producing Enterobacteriaceae--Indiana, 2016-2017
[3-5] There are several classes of carbapenemase-producing Enterobacteriaceae (CPE), which include non-metalloenzymes (Klebsiella pneumoniae carbapenemases (KPC), Guiana extendedspectrum [beta]-lactamases (GES), oxacillinase-type carbapenemases (OXA-48) and their derivatives) and metallo-[beta]-lactamases (MBL) (imipenemases (IMP), Verona integron-encoded MBL (VIM) and New Delhi metallo-[beta]-lactamase (NDM-1/2)).
Molecular detection of carbapenemase-producing genes in referral Enterobacteriaceae in South Africa: a short report
Nolte, "Development and evaluation of a real-time PCR assay for detection of Klebsiella pneumoniae carbapenemase genes," Journal of Clinical Microbiology, vol.
Fatal Donor-Derived Carbapenem-Resistant Klebsiella pneumoniae Infection in a Combined Kidney-Pancreas Transplantation
Carbapenem-resistant Enterobacteriaceae, particularly those that produce Klebsiella pneumoniae carbapenemase (KPC), are becoming increasingly problematic in the Chicago area, Dr.
Drug-resistant Klebsiella pneumoniae is a growing problem
Laboratory surveillance suggests substantial geographic variability, with Klebsiella pneumoniae carbapenemase (KPC) predominating in Quebec, whereas New Delhi metallo-P-lactamase (NDM) is most frequent in British Columbia (9,10).
Emergence of Carbapenemase-Producing Enterobacteriaceae, South-Central Ontario, Canada
Infection with Klebsiella pneumoniae carbapenemase (KPC)-producing Klebsiella pneumoniae in cancer patients.
Tailoring antimicrobials in febrile neutropenia: using faster diagnostic and communication tools to improve treatment in the era of extensively resistant pathogens
It was designed to address gram-negative bacteria that produce new beta-lactamase enzymes that have spread in the United States and Europe, particularly the Klebsiella pneumoniae carbapenemase enzyme.
The Medicines Company Selects Vabomere as US and European Trade Name for Meropenem-Vaborbactam, Stops Study Early
Background: Klebsiella pneumoniae carbapenemase (KPC)-producing K.
An Outbreak of Infections Caused by a Klebsiella pneumoniae ST11 Clone Coproducing Klebsiella pneumoniae Carbapenemase-2 and RmtB in a Chinese Teaching Hospital
However, clinically relevant carbapenemases belong to three of these classes, namely class A [beta]-lactamases such as Klebsiella pneumoniae carbapenemase (KPC) and Guiana extended-spectrum carbapenemase (GES), class B metallo-[beta]-lactamases such as Verona integron-mediated metallo-[beta]-lactamase (VIM), imipenemase (IMP) and New Delhi metallo-P-lactamase (NDM), and class D [beta]-lactamases including oxacillinase (OXA) subtypes such as OXA-48.
Invasive carbapenem-resistant Enterobacteriaceae infection at a paediatric hospital: a case series
An outbreak of infection due to (Beta) -lactamase Klebsiella pneumoniae carbapenemase 2-producing K.
Frequency of Class B Carbapenemases (M (Beta) L) in enterobacteriacae
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