Klebsiella pneumoniae carbapenemase


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Klebsiella pneumoniae carbapenemase

A plasmid-transferrable beta-lactamase (enzyme) carried by an increasing number of strains of Klebsiella pneumoniae as well as other Enterobacteriaceae. Hydrolysis of the beta-lactam ring renders many of the antibiotics—in particular, extended spectrum cephalosporins and carbapenems (imipenem, meropenem, and ertapenem)—ineffective.
References in periodicals archive ?
* Klebsiella pneumoniae carbapenemase (KPC), New Delhi metallo-beta-lactamase (NDM), Verona integron-mediated metallo-[beta]-lactamase (VIM), imipenemase (IMP), and oxacillinase-48-like carbapenemase (OXA-48).
[3-5] There are several classes of carbapenemase-producing Enterobacteriaceae (CPE), which include non-metalloenzymes (Klebsiella pneumoniae carbapenemases (KPC), Guiana extendedspectrum [beta]-lactamases (GES), oxacillinase-type carbapenemases (OXA-48) and their derivatives) and metallo-[beta]-lactamases (MBL) (imipenemases (IMP), Verona integron-encoded MBL (VIM) and New Delhi metallo-[beta]-lactamase (NDM-1/2)).
Nolte, "Development and evaluation of a real-time PCR assay for detection of Klebsiella pneumoniae carbapenemase genes," Journal of Clinical Microbiology, vol.
Carbapenem-resistant Enterobacteriaceae, particularly those that produce Klebsiella pneumoniae carbapenemase (KPC), are becoming increasingly problematic in the Chicago area, Dr.
Laboratory surveillance suggests substantial geographic variability, with Klebsiella pneumoniae carbapenemase (KPC) predominating in Quebec, whereas New Delhi metallo-P-lactamase (NDM) is most frequent in British Columbia (9,10).
It was designed to address gram-negative bacteria that produce new beta-lactamase enzymes that have spread in the United States and Europe, particularly the Klebsiella pneumoniae carbapenemase enzyme.
However, clinically relevant carbapenemases belong to three of these classes, namely class A [beta]-lactamases such as Klebsiella pneumoniae carbapenemase (KPC) and Guiana extended-spectrum carbapenemase (GES), class B metallo-[beta]-lactamases such as Verona integron-mediated metallo-[beta]-lactamase (VIM), imipenemase (IMP) and New Delhi metallo-P-lactamase (NDM), and class D [beta]-lactamases including oxacillinase (OXA) subtypes such as OXA-48.
An outbreak of infection due to (Beta) -lactamase Klebsiella pneumoniae carbapenemase 2-producing K.