Klebsiella pneumoniae carbapenemase


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Klebsiella pneumoniae carbapenemase

A plasmid-transferrable beta-lactamase (enzyme) carried by an increasing number of strains of Klebsiella pneumoniae as well as other Enterobacteriaceae. Hydrolysis of the beta-lactam ring renders many of the antibiotics—in particular, extended spectrum cephalosporins and carbapenems (imipenem, meropenem, and ertapenem)—ineffective.
References in periodicals archive ?
Overview of the epidemiology and the threat of Klebsiella pneumoniae Carbapenemases (KPC) resistance.
Genomic epidemiology of an endoscope-associated outbreak of Klebsiella pneumoniae carbapenemase (KPC)-producing K.
Carbapenem-resistant Escherichia coli harboring Klebsiella pneumoniae carbapenemase (Beta) -lactamases associated with long-term care facilities.
Two carbapenemase subclasses are especially problematic: Klebsiella pneumoniae carbapenemase (KPC) and New Delhi metallo-[beta]-lactamase-1 (NDM-1).
2) Production of Klebsiella pneumoniae carbapenemase (KPC) enzymes is the most common mechanism of resistance, while the incidence of zinc-dependent metallop-lactamases (VIM, IMP, and NDM types) is also increasing.
Gasink, et al found that severe illness, prior fluoroquinolone and extended- spectrum cephalosporin use are risk factors for isolation of Klebsiella pneumoniae carbapenemase (KPC)- producing K.
Carbapenem resistance as a result of Klebsiella pneumoniae carbapenemase (KPC; Class A), New Delhi metallo-beta-lactamase-1 (NDM-1; Class B) and OXAsubtypes (Class D) are thought to occur at low levels in Africa.
However, the most common mechanism of carbapenem resistance among Enterobacteriaceae in the United States remains the production of the Klebsiella pneumoniae carbapenemase (KPC).
Currently, the main acquired carbapenemases around the world are Klebsiella pneumoniae carbapenemase (KPC), oxacillinase-48 (OXA-48), and NDM.
Retrospective clinical data suggest that antibiotic combinations, including tigecycline (TIG) and polymyxin (POL), result in better outcomes than monotherapy against Klebsiella pneumoniae carbapenemase (KPC)-producing K.
Until recently Klebsiella pneumoniae carbapenemase (KPC) first detected in Klebsiella pneumoniae (molecular Class A enzyme), and Verona integron-encoded metallo-b- lactamase ( VIM) carbapenemase (molecular Class B enzyme) were considered to be the most frequent types of carbapenemases reported from countries including United States, Israel, Turkey, China, India, the United Kingdom, Greece and Nordic countries.
CRE infections in the United States are often mediated by acquisition of Klebsiella pneumoniae carbapenemase (KPC) expressed by Klebsiella spp.