KISS1

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KISS1

A gene on chromosome 1q32 that encodes a G protein-coupled receptor which suppresses metastases of melanomas and breast carcinomas without affecting their tumourigenicity. KISS1 may inhibit chemotaxis and invasion, and attenuate metastasis in melanomas.
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References in periodicals archive ?
Estradiol benzoate greatly increased kisspeptin expression, Fos protein expression, and kisspeptin+Fos protein expression (Fig.1, Table 1).
The second antibody was biotinylated goat antirabic serum (Vector, Burlingame, CA, USA) (1:250); visualisation was with nickel-enhanced diaminobenzidine (NiDAB) for Fos, and diaminobenzidine (DAB) for double-labelling of kisspeptin. The sections were first incubated with the Fos antibody, and the nickel DAB reaction was performed before incubation with kisspeptin antibody (1:1500).
Animals and humans lacking kisspeptin do not go through puberty and remain sexually immature.
In >13 thalassemic female T3 had a negative correlation (P<0.05) with BMI and hemoglobin, while a positive correlation (P13 years male T3 had a positive correlation (P<0.05) with kisspeptin. T4 in all four thalassemic groups had a significant positive correlation with hemoglobin (P13 years female had a significant positive correlation with BMI, ferritin and hemoglobin (P1000 ng/ml lead to iron overload in various organ like heart, liver and endocrine gland (Olivieri and Brittenham, 1997; Vichinsky, 2001).
Kisspeptin and neurokinin B levels were higher in the idiopathic CPP and PT groups compared to controls.
Impact of neonatal exposure to the ER [alpha] agonist PPT, bisphenol-A or phytoestrogens on hypothalamic kisspeptin fiber density in male and female rats.
Kisspeptin ve G protein coupled reseptor 54 (GPR54) GnRH noronlarinin pubertal aktivasyonunda onemli rol oynar.
Kisspeptin is the product of the KISS1 (1) (KiSS-1 metastasis suppressor) gene and is the ligand for the G-protein-coupled receptor, now known as the KISS1 receptor (KISS1R) [2] (1).
Dr Dhillo said: "The results of our study are exciting as they show that kisspeptin may be a novel method for restoring fertility to women with certain types of infertility.
The women were injected with either kisspeptin or a harmless but inactive salt solution.
Sathyapalan, "The role of kisspeptin signalling in the hypothalamic-pituitary-gonadal axis--current perspective," Endokrynologia Polska, vol.