Kineret(redirected from Kinneret)
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Pharmacologic class: Interleukin-1 (IL-1) blocker
Therapeutic class: Immunomodulator, antirheumatic
Pregnancy risk category B
Inhibits binding of IL-1 with IL type I receptors, thereby mediating immunologic, inflammatory, and other physiologic responses
Prefilled glass syringes: 100 mg/0.67 ml
Indications and dosages
➣ Moderately to severely active rheumatoid arthritis in patients ages 18 and older who don't respond to disease-modifying antirheumatics alone
Adults: 100 mg/day subcutaneously, given at same time each day
• Hypersensitivity to drug or Escherichia coli-derived protein
• Serious infections
Use cautiously in:
• immunosuppression, active infection, chronic illness, renal impairment
• elderly patients
• pregnant or breastfeeding patients
☞ Withhold drug and notify prescriber if patient shows signs or symptoms of active infection.
☞ Use extreme caution if patient is concurrently receiving drugs that block tumor necrosis factor (TNF), because of increased risk of serious infection.
• Give entire dose from prefilled syringe.
• Don't freeze or shake syringe.
GI: nausea, diarrhea, abdominal pain
Hematologic: thrombocytopenia, neutropenia
Respiratory: upper respiratory tract infection
Skin: rash, pruritus, injection site reaction or bruising, rash, erythema, inflammation
Other: flulike symptoms, infections
Drug-drug. Etanercept, infliximab, other drugs that block TNF: increased risk of serious infection
Live-virus vaccines: vaccine inefficacy
Drug-diagnostic tests. Neutrophils: decreased count
• Monitor CBC with white cell differential.
• Assess injection site for reactions.
☞ Tell patient to immediately report signs or symptoms of infection.
• Advise patient to report signs and symptoms of allergic response.
• Instruct patient to take drug at same time each day for best response.
• Teach patient about proper drug disposal (in puncture-resistant container). Also caution him against reusing needles, syringes, and drug product.
• Tell patient not to freeze or shake drug.
• As appropriate, review all other significant and life-threatening adverse reactions and interactions, especially those related to the drugs and tests mentioned above.
Pharmacologic: interleukin antagonists
Time/action profile (clinical response)
|Subcut||within 12 wk||unknown||unknown|
Adverse Reactions/Side Effects
Central nervous system
- injection site reactions (most frequent)
- infections (life-threatening)
- hypersensitivity reactions (rare)
Drug-Drug interaction↑ risk of serious infection with TNF blocking agents, such as etanercept.May ↓ antibody response to and increase the risk of adverse reactions from vaccines ; avoid concurrent administration of live vaccines.
Neonatal-Onset Multisystem Inflammatory Disease
- Assess for signs and symptoms of infection (fever, elevated WBC) prior to and periodically during therapy. Screen for latent TB prior to beginning therapy; treat if screen is positive. Anakinra should not be instituted in patients with active infections and should be discontinued if patient develops a serious infection.
- Observe patient for hypersensitivity reactions (urticaria, dyspnea, hypotension). Discontinue anakinra if severe reaction occurs. Medications (antihistamines, acetaminophen, corticosteroids, epinephrine) and equipment should be readily available in the event of a severe reaction.
- Rheumatoid Arthritis: Assess patient’s range of motion and degree of swelling and pain in affected joints before and periodically during therapy.
- Neonatal-Onset Multisystem Inflammatory Disease: Assess symptoms of NOMID (fever, rash, joint pain, vomiting, headache) prior to and periodically during therapy.
- Lab Test Considerations: Monitor neutrophil count prior to and during therapy, then monthly for 3 mo and quarterly thereafter for up to 1 yr.
Potential Nursing DiagnosesImpaired physical mobility (Indications)
Acute pain (Indications)
- Administration of higher than recommended doses did not result in higher responses.
- Subcutaneous: Administer 1 dose/day. Do not administer solutions that are discolored or contain particulate matter or are beyond expiration date. Provided in single-use prefilled syringes. Store in refrigerator; do not freeze. Remove from refrigerator and allow to reach room temperature for 30 min prior to injection. Avoid injecting into areas that are red or swollen.
- Instruct patient in correct technique for injection and care and disposal of equipment. Advise patient/parent to read Patient Information and Instructions for Use prior to starting therapy and with each Rx refill, in case of changes.
- Inform patient of the signs and symptoms of hypersensitivity reactions and injection site reactions (pain, erythema, swelling, purities, brusing, mass, inflammation, dermatitis, edema, urticaria, vesicles, warmth, and hemorrhage). Advise patient of appropriate actions if reactions occur.
- Advise patient to notify health care professional of all Rx or OTC medications, vitamins, or herbal products being taken and to consult with health care professional before taking other medications.
- Advise patients not to receive live vaccines during therapy with anakinra without consulting health care professional.
- Advise female patients to notify health care professional if pregnancy is planned or suspected, or if breastfeeding.
- Home Care Issues: Instruct patient and family on preparation and correct technique for administration of injection and care and disposal of equipment. Caution patients and caregivers not to reuse needles, syringes, or drug product.
- Reduction of signs and symptoms and slowed progression of moderate to severe active rheumatoid arthritis.
- Decrease in signs and symptoms of NOMID.