kinin

(redirected from Kinins)
Also found in: Dictionary, Thesaurus, Encyclopedia.
Related to Kinins: Prostaglandins, Cytokines

kinin

 [ki´nin]
the generic term for any of the polypeptides related in amino acid sequence and physiological activity to bradykinin and kallidin, formed by kallikrein-mediated cleavage of kininogens. Kinins are plasma proteins that increase vascular permeability, interact with prostaglandins to cause pain and smooth muscle contraction and to increase the migration of white blood cells during the inflammatory process, and act as potent renal vasodilators to increase the renal excretion of sodium.

ki·nin

(kī'nin),
Polypeptide hormones that are released from diffuse stores and not from specialized tissue. they are rapidly inactivated at the site of release.
[G. kineō, to move, + -in]

kinin

(kī′nĭn)
n.
Any of various structurally related polypeptides, such as bradykinin, that act locally to induce vasodilation and contraction of smooth muscle.

ki·nin

(kī'nin)
One of a number of substances having pronounced physiologic effects. Some are polypeptides, formed in blood in various pathologic processes, which stimulate visceral smooth muscle but relax vascular smooth muscle, thus producing vasodilation.
[G. kineō, to move, + -in]

kinin

One of a family of POLYPEPTIDES, released as a part of the inflammatory process, which increase the leakiness of small blood vessels and cause smooth muscle fibres to contract.

kinin

the old name for CYTOKININ.

ki·nin

(kī'nin)
Polypeptide hormones released from diffuse stores and not from specialized tissue, rapidly inactivated at the site of release.
[G. kineō, to move, + -in]
References in periodicals archive ?
Shen et al., "Postischemic brain injury is exacerbated in mice lacking the kinin B2 receptor," Hypertension, vol.
Scorpion (Buthus tamulus) venom toxicity on cardiopulmonary reflexes involves kinins via 5-HT3 receptor subtypes.
Couture, "Contribution of the central dopaminergic system in the antihypertensive effect of kinin B1 receptor antagonists in two rat models of hypertension," Neuropeptides, vol.
This study showed the distribution of the [B.sub.2] receptor binding sites of kinins in the spinal cord medulla cores and thoracic aorta, by quantitative autoradiography, as well as using real-time PCR to analyze gene expression of [B.sub.2] kinin receptor.
Furthermore, prior study has revealed that the reduction of kinin metabolism by ACEI might be involved in the beneficial effects exerted by these compounds in diabetic kidney functions [39].
LeebLundberg, "Kinins promote B2 receptor endocytosis and delay constitutive Bj receptor endocytosis," Molecular Pharmacology, vol.
The pain of Dry socket occurs because of release of kinins which are immediately available following tis- sue trauma,2 exposure of nerve endings to air, food and fluids in bare bone of the extraction socket1 and infec- tious process which releases tissue activators and pain mediators.7
The first phase is mediated through the release of histamine, serotonin and kinins whereas the second phase is related to the release of prostaglandin and slow reacting substances which peak at 3h (Vinegar et al.
Kininogens or family 3 cystatins are large precursor molecules of the vasoactive kinins. They are single chain glycoproteins, which serve a variety of biological functions such as kinin delivery, induction of endogenous blood coagulation cascade, and mediation of the acute phase response.
The ground substances changes may be a direct result of the insulting agent or may be mediated via histamines or kinins. (14,15)