Heterozygous mutations of the kinesin
KIF21A in congenital fibrosis of the extraocular muscles type 1 (CFEOM1).
transports RNA: isolation and characterization of an RNA-transporting granule," Neuron, vol.
Schnapp, "Trafficking of signaling modules by kinesin
motors," Journal of Cell Science, vol.
For their research, the scientists extracted microtubules from the brain tissue of cows, and mixed them kinesin
- a protein that attaches to the microtubules - and adenosine triphosphate (ATP) - often called the "molecular unit of currency" of intracellular energy transfer.
Similar biased Brownian motion was observed for a single headed kinesin
family protein, KIF1A that transports vesicles along microtubules in cells.
The connection of aPKC signal to GLUT4 vesicle trafficking appears to involve the actin cytoskeleton, Rabs, and molecular motors, as PKC[lambda]/[zeta] can impinge on Rac-mediated actin dynamics and can also regulate the interaction between Rab4 and kinesin
motors [72, 73].
Two other genes, ZNF408 encoding zinc finger protein 408 and KIF11 encoding kinesin
family member 11, are linked to FEVR, although the evidence of their association needs to be clarified.
Hirokawa, "KIF3A/B: A heterodimeric kinesin
superfamily protein that works as a microtubule plus end-directed motor for membrane organelle transport," Journal of Cell Biology, vol.
In the absence of Hh ligand, Gli3 is restricted to a microtubule complex composed of Kif7 (kinesin
family member 7), SuFu (suppressor of fused), CK1 (casein kinase 1), PKA (protein kinase A), and Gsk3[beta] (glycogen synthase kinase 3 beta) and is phosphorylated by PKA, GSK3[beta], and CK1.
Global Markets Direct's, 'Kinesin
Spindle Protein (KSP or Eg5) - Pipeline Review, H1 2016', provides in depth analysis on Kinesin
Spindle Protein (KSP or Eg5) targeted pipeline therapeutics.
Silva-Barrios, (36) evaluated the antigenicity of the rK346 antigen, a kinesin
of approximately 17.2 kDa whose primary sequence is principally composed of tandem repeats conferring its acidic character (isoelectric point: 4.6).