We already know that lack of Kindlin-1 in the skin leads to Kindler Syndrome
- a rare genetic disorder that results in skin blistering and sometimes leads to skin cancer.
Kindler Syndrome (KS) is a rare autosomal recessive genetic disorder manifesting as generalized dermatoses, described in 1954 by Theresa Kindler.
About 100 cases of Kindler syndrome have been reported in literature so far some from Arab World as well.
"EB has been categorized as encompassing five major types (Simplex, Junctional, Dystrophic, Kindler Syndrome
, Aquisita) and 31 subtypes, therefore it is commonly referred to as a group of disorders.
. Int J Dermatol, vol.42, no.9, pp.
Induction of senescence pathways in Kindler syndrome primary keratinocytes.
Unusual molecular findings in Kindler syndrome. Br J Dermatol 2007 Dec; 157(6):1252-1256.
Kindler syndrome (KS) is an autosomal recessive skin disorder characterized by traumatic acral blister formation in infancy and early childhood, progressive poikiloderma, cutaneous atrophy and increased photosensitivity.
(5.) Ashton GH: Kindler syndrome. Clin Exp Dermatol 2004;29:116-21.
BELFAST -- Identification of the gene mutation responsible for the blistering, mottling, and periodontitis of Kindler syndrome
should allow affected patients to take preventive measures such as sun protection and regular dental care beginning early in life to minimize the severity of the condition later on, Dr.
There are four major type of inherited epidermolysis bullosa: EB simplex (EBS), junctional EB (JEB), dystrophic EB (DEB) and Kindler syndrome
(1.) Yasukawa K, Sato-Matsumura KC, McMillan J et al: Exclusion of COL7A1 mutation in Kindler syndrome
. J Am Acad Dermatol 2002;46:447-50.