Kikuchi disease


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Ki·ku·chi disease

(kē-kū'chē),
necrotizing lymphadenitis of unknown etiology characterized by lymph node enlargement, associated with fever that subsides spontaneously. Most often seen in young women in Japan but appears in other countries.

Kikuchi disease

A rare, idiopathic lesion of young women, which is characterised by painful localised, usually cervical, lymphadenopathy. 

Clinical findings
Fever or upper-respiratory tract symptoms, weight loss, nausea, vomiting, night sweats.

Lab
Increased interferon-gamma, IL-6 , FasL in acute phase, anti-nuclear antibodies, elevated ESR; 50% of cases have a mild reduction in neutrophils and increase in lymphocytes. 

Prognosis
Benign, self-limited; usually resolves in 1 to 4 months.
 
Note: Some authors regard Kikuchi’s disease as a forme fruste of systemic lupus erythematosus.

Ki·ku·chi dis·ease

(ki-kū'chē di-zēz')
Necrotizing lymphadenitis of unknown etiology, most often encountered in young women in Japan but also in other parts of the world; lymph node enlargement, associated with fever; subsides spontaneously.
References in periodicals archive ?
KEYWORDS: Kikuchi Disease (KD), Hemolytic Uremic Syndrome (HUS), Acute Kidney Injury (AKI).
kansasii), reactive hyperplasia, cat scratch disease, fungal infection, toxoplasma lymphadenitis, sarcoidosis, berylliosis, bacterial adenitis, and Kikuchi disease (idiopathic histiocytic necrotizing lymphadenitis).
Hemophagocytic lymphohistiocytosis preceded by Kikuchi disease in children.
The main diseases that should be excluded are some malign diseases such as lymphoma, Kaposi's sarcoma, angiosarcoma, neck metastasis of malign tumors, dermatofibrosarcoma protuberance, cylindroma as well as some benign conditions such as hemangioma, pyogenic granuloma, Kikuchi disease, Mikulicz disease, angioimmunoblastic lymphadenopathy, ESAH and parasite diseases such as toxoplasmosis that may also cause increases in serum IgE levels and blood eosinophil counts (2-4,8,11).
(8.) Kwon SY, Kim TK, Kim YS, Lee KY, Lee NJ, Seol HY CT findings in Kikuchi disease: analysis of 96 cases.
Seol, "CT findings in Kikuchi disease: analysis of 96 cases," American Journal of Neuroradiology (AJNR), vol.
Kikuchi disease:Arare cause of fever of unknown origin.
A 26-year-old woman presented with recurrent Kikuchi disease 7 years after her initial episode.
Some case reports show parotidomegaly and thyroiditis with kikuchi disease.5
For the authors, remains the impression that the AKF appeared in a moment when KFD had stronger symptoms and when adequate treatment of Kikuchi disease reduced kidney failure.
Autoimmune manifestations of Kikuchi disease. Semin Arthritis Rheum 2012;41(6):900-6.
Kikuchi disease is also known as Kikuchi-Fujimoto disease and histiocytic necrotizing lymphadenitis.