Kikuchi's disease

Kikuchi disease

A rare, idiopathic lesion of young women, which is characterised by painful localised, usually cervical, lymphadenopathy. 

Clinical findings
Fever or upper-respiratory tract symptoms, weight loss, nausea, vomiting, night sweats.

Lab
Increased interferon-gamma, IL-6 , FasL in acute phase, anti-nuclear antibodies, elevated ESR; 50% of cases have a mild reduction in neutrophils and increase in lymphocytes. 

Prognosis
Benign, self-limited; usually resolves in 1 to 4 months.
 
Note: Some authors regard Kikuchi’s disease as a forme fruste of systemic lupus erythematosus.
Segen's Medical Dictionary. © 2012 Farlex, Inc. All rights reserved.

Kikuchi's disease

A disease usually affecting young women who present with painless enlarged lymph nodes in the neck or elsewhere, fever and liver damage. The condition may be confused with malignant LYMPHOMA or HODGKIN'S DISEASE but usually settles within three months.
Collins Dictionary of Medicine © Robert M. Youngson 2004, 2005
References in periodicals archive ?
Kikuchi's Disease Associated with Hemophagocytosis.
Kikuchi's disease (histiocytic necrotizing lymphadenitis): a clinicopathologic study of 79 cases with an analysis of histologic subtypes, immunohistology, and DNA ploidy.
Kikuchi's disease causing persistent fever and iliac lymphadenopathy in an 8-year-old boy.
SLE Developing in a Follow-Up Patient of Kikuchi's Disease: A Rare Disorder.
Chan, "Haemophagocytic syndrome and histiocytic necrotising lymphadenitis (Kikuchi's disease)," Journal of Clinical Pathology, vol.
Kikuchi-Fujimoto disease (KFD) is an enigmatic, benign and self-limited syndrome characterized by regional lymphadenopathy with tenderness, predominantly in the cervical region, usually accompanied by mild fever and night sweats.1 Kikuchi's disease, or necrotizing histolytic lymphadenitis, is a rare disease that presents predominantly in young women in their 20s and 30s from the Far East.3
Besides the above mentioned causes of lymph node affliction, we noted three cases of Kimura's disease, two cases of Rosai Dorfman disease (sinus histiocytosis with massive lymphadenopathy) and a single case of Kikuchi's disease. All 3 patients were less than 15 years of age.
Entire picture is suggestive of Kikuchi's disease (Figure 3).
Histiocytic necrotizing lymphadenitis (Kikuchi's disease): In situ end-labeling, immunohistochemical, and serologic evidence supporting cytotoxic lymphocyte-mediated apoptotic cell death.
(4.) Kim YM, Lee YJ, Nam SO, Park SE, Kim JY Lee EY Hemophagocytic syndrome associated with Kikuchi's disease. J Korean Med Sci 2003; 18(4): 592-4.
The characteristic histologic appearance of kikuchi's disease resembles that of malignant lymphoma.1 KFD patients typically present with painless but sometimes tender, enlarged unilateral cervical lymph nodes.