Ki-1 lymphoma

Ki-1 lymphoma(s)

A heterogeneous group of childhood lymphomas, the cells of which react against the monoclonal antibody Ki-1, which usually involves the skin, soft tissue, bone, GI tract, rarely CNS  and pericardium  DiffDx Metastatic undifferentiated CA, amelanotic melanoma, malignant sinus histiocytosis; despite its 'ugly' histology, KLs may respond to chemotherapy with prolonged remission or complete cure. See Lymphoma.
References in periodicals archive ?
Intraoral presentation of anaplastic large-cell Ki-1 lymphoma in association with HIV infection.
A translocation involving a specific breakpoint (q35) on chromosome 5 is characteristic of anaplastic large cell lymphoma ('Ki-1 lymphoma').
Diagnosis of t(2;5)(p23;q35)associated Ki-1 lymphoma with immunohistochemistry.
Childhood Ki-1 lymphoma: presentation as a buttock mass.
Intraoral presentation or anaplastic large-cell Ki-1 lymphoma in association with HIV infection.
Anaplastic large-cell Ki-1 lymphoma. Pulmonary presentation mimicking miliary tuberculosis.
Anaplastic large cell lymphoma (ALCL) is an aggressive, but potentially curable T-cell lymphoma, originally called Ki-1 lymphoma due to its characteristic immunoreaction with the activation antigen CD30 (Ki-1) (2,3,4).
CD30-positive large cell lymphomas ('Ki-1 lymphoma') are associated with a chromosomal translocation involving 5q35.
CD30 is a transmembrane glycoprotein and is a member of the tumor necrosis factor receptor superfamily.[1] CD30 plays a role in regulating the function or proliferation of normal lymphoid cells.[2] The Ki-1 monoclonal antibody was first identified as useful for immunohistochemical staining in identifying Reed-Sternberg cells in Hodgkin lymphoma.[2-4] Subsequently, CD30 proved useful in helping define anaplastic large cell lymphoma (ALCL), which was initially known as Ki-1 lymphoma. However, it is now known that morphology, histology, and molecular identification of the t(2;5)(p23;q35) translocation are most critical in identifying ALCL, since numerous other lymphomas and carcinomas may have CD30 expression as a nonspecific indicator of cellular activation.
Diagnosis of t(2;5)(p23;q35)-associated Ki-1 lymphoma with immunohistochemistry.
Sarcomatoid variant of anaplastic large cell Ki-1 lymphoma. Am J Surg Pathol.
Childhood Ki-1 lymphoma complicated with multiple bone destruction.