17-ketosteroid

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17-ketosteroid

(ke-to-ster'oyd)
One of a group of neutral steroids having a ketone group in carbon position 17. They are produced by the adrenal cortex and gonads and appear normally in the urine. Among them are androsterone, dehydroisoandrosterone, corticosterone, and 11-hydroxyisoandrosterone. A greater than normal or less than normal excretion in the urine is indicative of certain endocrine disorders such as adrenal adenomas or Cushing's syndrome.
See: perhydrocyclopentanophenanthrene
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References in periodicals archive ?
Urinary 17-alpha ketosteroids are usually normal or slightly elevated (1, 2 and 4) in contrast to adrenal tumors.
A myriad of determinands caught his interest: magnesium, calcium, beryllium, gold, copper, iron, and zinc; phosphorous, chloride, and protein-bound iodine; creatinine, urea, bilirubin, proteins, estrogens, nucleic acids, ketosteroids, and haptoglobin; cholesterol, triglycerides, free fatty acids, and phospholipids; salicylates, barbiturates, thiobarbiturates, methotrexate, carbon monoxide, methanol, and ethanol; alkaline phosphatase, glucose-6-phosphatase, 5-'nucleotidase, cholinesterase, and creatine kinase.
Preparation of trimethylsilyl, triethylsilyl and tert-butyldimethylsilyl enol ethers from ketosteroids for investigations by gas-chromatography and mass-spectrometry.