The platform differentiates the semi-synthetic ketolides
telithromycin and solithromycin, which have been associated with significant liver injury, from the commercially marketed macrolides azithromycin and clarithromycin.
The correct statement is that ketolides
exhibit concentration-dependent killing and have prolonged persistence and the PK/PD indices responsible for efficacy are AUC24/MIC.
Macrolides and Ketolides
: Azithromycin, Clarithromycin, Telithromycin.
(e.g., telithromycin) are highly active against F.
(190.) IDSA Guidelines, supra note 13, at 1094 (listing, among other therapies, a number of antibiotic drugs not recommended to treat Lyme disease: "vancomycin, metronidazole, tinidazoleamantadine, ketolides
, isoniazid, trimethoprim, sulfamethoxazole, fluconazole, [and] benzathine penicillin G").
belong to the [MLS.sub.B] family, and telithromycin is the first commercially available ketolide
Compounds belonging to the class of aminoglycosides, fluoroquinolones, ketolides
result in former killing.
Macrolide-resistant streptococcus pneumoniae in Canada during 1998-1999: Prevalence of mef(A) and erm(B) and susceptibilities to ketolides
. Antimicrob Agents Chemother 2001; 45: 2147-2150.
The drug, cethromycin, belongs to a class of antibiotics called ketolides
that may prevent infectious bacteria from becoming resistant to treatment, a growing problem with current medicines.
The studies compared short courses of oral macrolide antibiotics, fluoroquinolones, ketolides
, or beta-lactam antibiotics.
In adults, the most common antibiotics recommended for sinus treatment are Amoxicillin, Cephalosporins, Macrolides, Ketolides
, and Quinolones.
The next describes classes of agents and includes chapters on beta-lactam antibiotics; peptide antibiotics; lincosamides, pleuromutilins, and streptogramins; macrolides, azalides, and ketolides
; aminoglycosides; tetracyclines and glycylcyclines; chloramphenicol, thiamphenicol, and florfenicol; sulfomanides, diaminopyrimidines, and their combinations; fluorquinolones; antifungal chemotherapy agents; and antiviral chemotherapy agents.