Resistance to macrolide, lincosamide, streptogramin, ketolide
, and oxazolidinone antibiotics.
50] and leakage of marker enzymes for drugs from macrolide and ketolide
series and further comparison of [IC.
The newer classes of streptogramins (Synercid[R]) and oxazolidinones (Zyvox[R]), both used to treat drug resistant staphylococcal infections, also work by inhibiting protein synthesis, as does the new ketolide
, telethromycin (Bryskier, 2005c.
antibiotic remains approved for treatment of mild to moderate community-acquired pneumonia (CAP) in patients aged 18 and over.
48) found that in vivo drug disposition of ABT-773, a ketolide
antibiotic that is a substrate for both CYP3A and P-glycoprotein, depends on the CYP3A5, but not the MDR1 genotype.
azithromycin, erythromycin, or any other macrolide or ketolide
Telithromycin: an oral ketolide
for respiratory infections.
Telithromycin (HMR 3647) is a new ketolide
antimicrobial that was developed for the treatment of community-acquired respiratory truer infections.
Results from the Prospective Resistant Organism Tracking and Epidemiology for the Ketolide
Telithromycin (PROTEKT US) surveillance study, covering isolates collected during 2000-2004, indicate that the prevalence of mef(A) is decreasing, and isolates harboring erm(B) and mef(A) genes are becoming increasingly common (13).
SAN FRANCISCO -- Clinical signs and symptoms of acute bacterial exacerbation of chronic bronchitis improved in patients treated with 5 days of an experimental ketolide
antibiotic, cethromycin, or 7 days of levofloxacin, David A.
Objective: Telithromycin, the first approved ketolide
antibiotic, was developed to treat community-acquired respiratory tract infections, including acute bacterial maxillary sinusitis (ABMS).
erythromycin or any macrolide or ketolide
antibiotic should not take