The archaeal pyruvate and alpha ketoglutarate generated by the action of GDH on glutamate can suppress NFKB producing immunosuppression and decrease in cytokine secretion.
Alpha ketoglutarate inhibits the transcription factor HIF alpha.
Total cholesterol, lucose, and electrolytes in piglets serum after a- ketoglutarate
(AKG) and dexamethasone treatment dutiny prenatal and neonatal life.
In this syndrome, intracellular and extracellular oedema, glial cell proliferation, neuronal demyelination, and cellular degeneration may occur in the central nervous system (CNS), due to thiamine deficiency, which is the co-factor of enzymes such as transketolase, pyruvate dehydrogenase and alpha ketoglutarate
Glutamate dehydrogenase (GDH) a mitochondrial enzyme catalyses the oxidative deamination of glutamate providing a- ketoglutarate to the Krebs cycle (Reddy and Venugopal 1990).
The GDH activity (Table I) in the present study showed a progressive enhancement in all tissues (gill muscle and liver) throughout the exposure suggesting a developing need for a- ketoglutarate.
05); however, the levels of methylmalonic acid, 5-hydroxyhexanoic acid and 2- ketoglutarate
in the males were higher than in the females (Pless than 0.
This is the ester that is best known and understood as cofactor to the decar-boxylating component of the pyruvic, the branched chain and alpha ketoglutarate
complexes and transketo-lase.
The activities of fatty acid synthetase, ketoglutarate
dehydrogenase (EC 1.
Rapid diagnosis of pyruvate and ketoglutarate
dehydrogenase deficiencies in platelet-enriched preparations from blood.
Andersen, "Oxidative [alpha]- ketoglutarate
dehydrogenase inhibition via subtle elevations in monoamine oxidase B levels results in loss of spare respiratory capacity: implications for Parkinson's disease," The Journal of Biological Chemistry, vol.
Anti-mitochondrial antibodies (AMA) directed against the E2 subunit of pyruvate dehydrogenase (PDH-E2) which is a member of the inner mitochondrial membrane-expressed oxoacid dehydrogenase complex, and ketoglutarate
dehydrogenase are present in 95% of the patients3.