Keshan disease


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A fatal heart disease first reported in Keshan County of the greater metropolitan Qiqihar of the Heilongjiang province, mainland China, which affects children and young women; the condition has since been found elsewhere—e.g., New Zealand and Finland—where soil selenium levels are low
Pathogenesis Selenium deficiency in water supply, resulting in dilated cardiomyopathy and increased platelet aggregation due to decreased free radical salvage by glutathione peroxidase
Management Selenium

Ke·shan dis·ease

(kē'shăn di-zēz')
Cardiomyopathy due to the deficiency of selenium found in women and children in Keshan, China.
References in periodicals archive ?
Selenium deficiency can cause a series of symptoms, such as cardiovascular disease, Kaschin-Beck disease and Keshan disease.
32 mg/kg among individuals (n = 366) with Keshan Disease (caused by selenium deficiency) and 0.
Serum biomarkers of Keshan disease assessed using a protein profiling approach based on ClinProt technique.
Selenium is also related to other diseases involving tissue damage, such as Keshan disease (heart disease), Kaschin disease (bone disease) and myxedematosus endemic cretinism.
Keshan disease is a cardiomyopathy of children and young women and manifests as acute or chronic cardiac enlargement and arrhythmia.
Johnson CC, Ge X, Green KA, Liu X (2000) Selenium distribution in the local environment of selected villages of the Keshan Disease belt, Zhangjiakou District, Hebei Province, People's Republic of China.
Keshan disease has been reported in areas of China where selenium soil levels are extremely low.
It is well known that Se, Zn, and Cu in serum can affect certain he art diseases such as Keshan disease, heart failure, cardiomyopathy, and atherosclerosis (1-11).
In parts of China - where selenium levels in the soil are at their lowest - selenium deficiency is linked to Keshan Disease, which causes poor heart function.
Selenium deficiency, although rare, is associated with Keshan disease, which is a type of cardiomyopathy affecting mainly children and young women primarily in China where selenium intake is low.
The most common signs of selenium deficiency seen in Keshan Disease are an enlarged heart and poor heart function (11).
In 1979, Chinese scientists reported the relationship of selenium to Keshan disease, a form of heart disease found in children and young women in a large area of China where soil is deficient in selenium.