Keshan disease

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A fatal heart disease first reported in Keshan County of the greater metropolitan Qiqihar of the Heilongjiang province, mainland China, which affects children and young women; the condition has since been found elsewhere—e.g., New Zealand and Finland—where soil selenium levels are low
Pathogenesis Selenium deficiency in water supply, resulting in dilated cardiomyopathy and increased platelet aggregation due to decreased free radical salvage by glutathione peroxidase
Management Selenium

Ke·shan dis·ease

(kē'shăn di-zēz')
Cardiomyopathy due to the deficiency of selenium found in women and children in Keshan, China.
References in periodicals archive ?
A partial list of past recipients includes: James Cecil Smith, USDA Nutrition Institute; Keshan Disease Research Groups at the Chinese Academy of Medical Sciences and X'ian Medical College; Forrest H.
Keshan disease has been reported in areas of China where selenium soil levels are extremely low.
Although this has not resulted in widespread goitre, hypothyroidism, thyroid disorders or Keshan disease, intakes of iodine and selenium are below recommended intakes.
It is well known that Se, Zn, and Cu in serum can affect certain he art diseases such as Keshan disease, heart failure, cardiomyopathy, and atherosclerosis (1-11).
The Keshan disease is characterized by the presence of multi-focal necrosis and fibrous replacement of the myocardial tissue.
In parts of China - where selenium levels in the soil are at their lowest - selenium deficiency is linked to Keshan Disease, which causes poor heart function.
Selenium deficiency, although rare, is associated with Keshan disease, which is a type of cardiomyopathy affecting mainly children and young women primarily in China where selenium intake is low.
In this region two endemic diseases, Keshan disease (juvenile cardiomyopathy) and Kashin-Beck disease (osteoarthropathy), have been reported.
In 1979, Chinese scientists reported the relationship of selenium to Keshan disease, a form of heart disease found in children and young women in a large area of China where soil is deficient in selenium.
People deficient in the mineral tend to develop Keshan disease, an inflammatory heart disease.
Clinically, the affliction known as Keshan disease "looks like congestive heart failure, except that it occurs in young children," says Levander.
Human selenium deficiency can have a variety of expression modes, and the common expression modes include: myalgia, myositis, myocardial fatty change, Keshan disease, hemolytic anemia, bone changes (Kashin-Beck disease), etc.