Keshan disease


Also found in: Wikipedia.
A fatal heart disease first reported in Keshan County of the greater metropolitan Qiqihar of the Heilongjiang province, mainland China, which affects children and young women; the condition has since been found elsewhere—e.g., New Zealand and Finland—where soil selenium levels are low
Pathogenesis Selenium deficiency in water supply, resulting in dilated cardiomyopathy and increased platelet aggregation due to decreased free radical salvage by glutathione peroxidase
Management Selenium

Ke·shan dis·ease

(kē'shăn di-zēz')
Cardiomyopathy due to the deficiency of selenium found in women and children in Keshan, China.
References in periodicals archive ?
Studies showed that erucic acid could trigger the development of Keshan disease, inflammation and calcification of arteries.
Selenium deficiency in humans causes a variety of endemic diseases, including Keshan disease, Kaschin-Beck disease, and goiters.
In the rare cases that one is deficient, it can cause heart problems such as Keshan disease, joint problems such as Kashen-Beck disease, or infertility.
Intake of excess selenium is associated with Keshan disease, which causes an enlarged heart, cardiac arrhythmias, and congestive heart failure [10, 11].
Selenium deficiency can cause a series of symptoms, such as cardiovascular disease, Kaschin-Beck disease and Keshan disease. The Se content of the soil is typically low, and there are more than 40 countries and regions worldwide where people experience Se deficiency.
In addition, a Chinese study reported an average hair Se concentration of 0.32 mg/kg among individuals (n = 366) with Keshan Disease (caused by selenium deficiency) and 0.45 mg/kg among 200 controls (Yang et al.
Serum biomarkers of Keshan disease assessed using a protein profiling approach based on ClinProt technique.
Selenium is also related to other diseases involving tissue damage, such as Keshan disease (heart disease), Kaschin disease (bone disease) and myxedematosus endemic cretinism.
Keshan disease is a cardiomyopathy of children and young women and manifests as acute or chronic cardiac enlargement and arrhythmia.
Johnson CC, Ge X, Green KA, Liu X (2000) Selenium distribution in the local environment of selected villages of the Keshan Disease belt, Zhangjiakou District, Hebei Province, People's Republic of China.
Selenium deficiency is associated with Keshan disease, a fatal form of cardiomyopathy.
It is well known that Se, Zn, and Cu in serum can affect certain he art diseases such as Keshan disease, heart failure, cardiomyopathy, and atherosclerosis (1-11).