keratin

(redirected from Keratins)
Also found in: Dictionary, Thesaurus, Encyclopedia.
Related to Keratins: actin, hard keratin

keratin

 [ker´ah-tin]
a scleroprotein that is the principal constituent of epidermis, hair, nails, horny tissues, and the organic matrix of the enamel of the teeth. Its solution is sometimes used in coating pills when the latter are desired to pass through the stomach unchanged.

ker·a·tin

(ker'ă-tin),
Collective name for a group of proteins that form the intermediate filaments in epithelial cells. Keratins have a molecular weight between 40 kD and 68 kD and are separated one from another by electrophoresis and isoelectric focusing; thus separated, they are sequentially numbered from 1-20, and also subdivided into low, intermediate, and high molecular weight proteins. According to their isoelectric mobility they are either acidic or basic. In general, each acidic keratin protein has its basic equivalent with which it is paired to form the intermediate filaments; some keratin proteins, however, occur unpaired. Various epithelial cells contain different keratin proteins, in a tissue-specific manner. Antibodies to keratin proteins are widely used for histologic typing of tumors, and are especially useful for distinguishing carcinomas from sarcomas, lymphomas, and melanomas.
Synonym(s): ceratin, cytokeratin
[G. keras (kerat-), horn, + -in]

keratin

(kĕr′ə-tĭn)
n.
1. Any of a class of filamentous proteins that are abundant in the cytoskeleton of vertebrate epithelial cells and are the main constituents of the outer layer of skin and tough epidermal structures such as hair, nails, hooves, feathers, and claws.
2. Material composed principally of keratin proteins.

ke·rat′i·nous (kə-răt′n-əs) adj.

ker·a·tin

(ker'ă-tin)
A scleroprotein or albuminoid present in hair and nails; it contains a relatively large amount of sulfur, is insoluble in gastric juice, and is sometimes used for coating tablets that are intended to be dissolved only in the intestine.
Synonym(s): cytokeratin.
[G. keras (kerat-), horn, + -in]

keratin

A hard protein (scleroprotein) of cylindrical, helical molecular form occurring in horny tissue such as hair and nails and in the outer layers of the skin. Hair and nails consist almost wholly of keratin. Keratins are insoluble and cannot generally be split by PROTEOLYTIC enzymes.

keratin

a hard, fibrous, sulphur-containing protein with an alpha-helix structure, found in the epidermis of vertebrates, mainly in the outermost layers of skin. Keratin can have several forms: in scales, feathers, hooves, horns, claws and nails it is hard, while wool and hair are made up of a soft and flexible form.

Keratin

A tough, nonwater-soluble protein found in the nails, hair, and the outermost layer of skin. Human hair is made up largely of keratin.

ker·a·tin

(ker'ă-tin)
Collective name for a group of proteins that form intermediate filaments in epithelial cells. Keratins have a molecular weight of 40-68 kD and are either acidic or basic. Antibodies to keratin proteins are widely used for histologic typing of tumors and are especially useful for distinguishing carcinomas from sarcomas, lymphomas, and melanomas.
[G. keras (kerat-), horn, + -in]

Patient discussion about keratin

Q. skins does excrete oil and keratin what exactly is the whitish cape up that you can squeeze out from underskin

A. It sounds like you refer to sebum, an oily substance secreted by (how surprising :) ) sebaceus glands attached to the hair root. It's important for the skin, although abnormal secretion of it may cause diseases such as acne.

You may read more here:
http://en.wikipedia.org/wiki/Sebum#Sebum

More discussions about keratin
References in periodicals archive ?
Keratins that form the intermediate filaments are expressed exclusively in the epithelial cells regardless of the germ layer origin of these cells.
Keratin solution was extracted from the prepared hairs using modification Shindai method [16].
Similarly, multilayer keratin dressings and keratin matrix dressings are used for moderate to highly exuding wounds.
Keratin NF membranes (NFMs) have demonstrated good adsorption properties for heavy metals ions [15, 16], VOCs [17], and dyes [18].
Intact hair removal from leather can be done by detaching hair root follicle keratin using keratinases without any adverse effect.
Keratinase is an extracellular, robust enzyme, having a wide temperature and pH range and is largely serine or metalloprotease, produced in the presence of keratin. Keratinase attacks the disulfide bonds of keratin to degrade it.
Characterization of cardiomyocytes with specific markers revealed that they can attach, grow and show spontaneous contractions on keratin coated substrates similar to fibronectin/gelatin coated surfaces.
Total SDS-Soluble Keratin. Total SDS-soluble keratin was prepared by extracting mouse hair (2 mg) twice with 50 mM [Na.sub.2]HP[O.sub.4],20 mM NaOH, 25 mM DTT, and 1% SDS (200 [micro]l, 65[degrees]C, 1 h each).
* Keratin, a structural component of hair, nails, and the outer layer of skin,
Meanwhile, European researchers identified KLHL24 mutations in families from Finland, Germany, Israel, Italy, Switzerland, and Qatar and confirmed that these mutations affect the equilibrium between intermediate keratin filaments and keratin breakdown that is necessary for skin integrity (Am J Hum Genet.
Cashmere has a very good textile performance, which is closely related to the keratin component and structure.
It is caused by mutations in keratin genes KRT6a, KRT6b, KRT6c, KRT16, KRT17.