FGF10(redirected from Keratinocyte growth factor 2)
FGF10A gene on chromosome 5p13-p12 that encodes fibroblast growth factor 10 of the FGF family, which bind heparin and have a broad range of cellular activities, including cell survival, division, differentiation and migration, embryonic development, morphogenesis, tissue repair, tumour growth and invasion. Its name notwithstanding, FGF10 is mitogenic for keratinocytes but has little effect on fibroblasts; FGF10 interacts with FGF receptors FGFR1 and -2.
Defects in FGF10 cause autosomal dominant aplasia of lacrimal and salivary glands and lacrimo-auriculo-dento-digital syndrome (LADDS).
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