FGF7

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FGF7

A gene on chromosome 15q21.2 that encodes fibroblast growth factor 7 of the FGF family, which bind heparin and have a broad range of cellular activities, including cell survival, division, differentiation and migration, embryonic development, morphogenesis, tissue repair, tumour growth and invasion. FGF7 is a potent epithelial cell-specific growth factor, which is mitogenic for keratinocytes, but has little effect on fibroblasts; it is required for normal branching morphogenesis. FGF7 interacts with FGF2 receptor (FGFR2).
References in periodicals archive ?
Vescarelli et al., "Potential prognostic and diagnostic application of a novel monoclonal antibody against keratinocyte growth factor receptor," Molecular Biotechnology, vol.
Longaker, "Induction of keratinocyte growth factor expression is reduced and delayed during wound healing in the genetically diabetic mouse," The Journal of Investigative Dermatology, vol.
Randomized phase I trial of recombinant human keratinocyte growth factor plus chemotherapy: Potential role as mucosal protectant.
Direct application of keratinocyte growth factor, basic fibroblast growth factor and transforming growth factor-alpha during healing of tympanic membrane perforation in glucocorticoid-treated rats.
The product is said to target the skin's DNA with keratinocyte growth factor. The serum creates new cells eight times faster than the skin can on its own.
The Food and Drug Administration has approved the recombinant human keratinocyte growth factor palifermin as the only drug indicated to reduce the incidence and duration of severe oral mucositis in patients with hematologic cancers who require hematopoietic stem cell transplantation after chemoradiotherapy.
Cancer patients who suffer the pain and complications of oral mucositis may find relief in a drug called palifermin (recombinant human keratinocyte growth factor), according to clinical trial results published in the Dec.
Keratinocyte growth factor inhibits GVHD after allogeneic BMT in mice
Keratinocyte Growth Factor (KGF-2) entered phase II studies last February.
Exposure of DU-145 AI prostate cancer cells transfected with an AR expression vector and a chloramphenicol acetyltransferase (CAT) reporter gene to keratinocyte growth factor (KGF), epidermal growth factor (EGF), or insulin-like growth factor 1 (IGF-1) could activate CAT gene expression in the absence of androgen (27).
Belleudi et al., "Up-modulation of the expression of functional keratinocyte growth factor receptors induced by high cell density in the human keratinocyte HaCaT cell line," Cell Growth & Differentiation, vol.
Another function of this factor is to suppress TGF-[beta] in the stimulation of extracellular matrix (ECM) production, but on the other hand it indirectly acts on reepithelialization by inducing keratinocyte growth factor production, together with IL-1 [25, 33].