KRT8

(redirected from Keratin 8)
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KRT8

A gene on chromosome 12q13.13 that encodes a type-II cytokeratin that heteropolymerises to form intermediate filaments in epithelial cell cytoplasm. The KRT 8 typically dimerises with KRT 18 to form an intermediate filament in simple single-layered epithelial cells. KRT8  plays a role in maintaining cellular structural integrity, in signal
transduction and cell differentiation.

Molecular pathology
KRT8 mutations cause cryptogenic cirrhosis.
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Yeh and Miller have shown in their communication that AE3 is more sensitive than AE1/AE3 in detecting certain type II keratins, such as keratin 8, which is commonly expressed by fibroblastic-type reticulum cells, a phenomenon similar to our findings between AE1/AE3 and pancytokeratin or CAM5.
Keratin 8 gene mutations were detected in liver explants from 5 of 55 patients with cryptogenic liver disease and none of 98 patients with noncryptogenic liver disease.