KRT8

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KRT8

A gene on chromosome 12q13.13 that encodes a type-II cytokeratin that heteropolymerises to form intermediate filaments in epithelial cell cytoplasm. The KRT 8 typically dimerises with KRT 18 to form an intermediate filament in simple single-layered epithelial cells. KRT8  plays a role in maintaining cellular structural integrity, in signal
transduction and cell differentiation.

Molecular pathology
KRT8 mutations cause cryptogenic cirrhosis.
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The gene functions of this cluster are diverse containing among others, Ly6d (lymphocyte antigen 6 complex), a lymphocytic marker; Cstb (cathespin), an intracellular thiol inhibitor; Nqo1 (DT-diaphorase) a two-electron quinone oxidoreductase whose expression is often associated with redox stress; and another member of the annexin family, others of which are in the cluster shown in Figure 3A; and Krt8 (Keratin 8), commonly associated with Mallory body formation.
Also overexpressed, though not differentially between the mouse strains, was the Krt8 (Keratin 8) gene (Figure 3C).
Yeh and Miller have shown in their communication that AE3 is more sensitive than AE1/AE3 in detecting certain type II keratins, such as keratin 8, which is commonly expressed by fibroblastic-type reticulum cells, a phenomenon similar to our findings between AE1/AE3 and pancytokeratin or CAM5.2 (antikeratin 8, 18) in our study.
Keratin 8 gene mutations were detected in liver explants from 5 of 55 patients with cryptogenic liver disease and none of 98 patients with noncryptogenic liver disease.