KRT14

(redirected from Keratin 14)
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KRT14

A gene on chromosome 17q12-q21 that encodes a type-I intermediate filament keratin, which typically forms a heterotetramer with KRT5 (type-II) keratins that together form the cytoskeleton of epithelial cells.

Molecular pathology
KRT14 mutations are associated with epidermolysis bullosa simplex.
References in periodicals archive ?
As previously reported in EBS, immunostaining for keratin 14 is positive, outlining areas of cleavage within the basal cell layer of the skin.
15,17,23,24) In contrast, keratin 14 and high-molecular-weight keratins detected by the antibody 34pE12 expression is less common.
The disorder is due to gene defects that result in a lack of one or both of two of these proteins, keratin 5 (K5) and keratin 14 (K14).