KRT14

(redirected from Keratin 14)
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KRT14

A gene on chromosome 17q12-q21 that encodes a type-I intermediate filament keratin, which typically forms a heterotetramer with KRT5 (type-II) keratins that together form the cytoskeleton of epithelial cells.

Molecular pathology
KRT14 mutations are associated with epidermolysis bullosa simplex.
References in periodicals archive ?
'All these mutations target the initiation codon of methionine." As previously reported in EBS, immunostaining for keratin 14 is positive, outlining areas of cleavage within the basal cell layer of the skin.
Basally expressed keratin 14 is a known direct transcriptional target of [DELTA]Np63[alpha] [64].
(15,17,23,24) In contrast, keratin 14 and high-molecular-weight keratins detected by the antibody 34pE12 expression is less common.
The disorder is due to gene defects that result in a lack of one or both of two of these proteins, keratin 5 (K5) and keratin 14 (K14).
"Gene-corrected graft sites showed fully differentiated epidermis with spinous and granular layers, which were positive for epidermal markers keratin 14, keratin 1, and loricirin resembling normal skin," Dr.