KRT10

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KRT10

A gene on chromosome 17q21 that encodes a type-I (acidic) member of the cytokeratin family, which belongs to the superfamily of intermediate filaments, that with actin microfilaments and microtubules forms the epithelial cell cytoskeleton.

Molecular pathology
KRT10 mutations cause epidermolytic hyperkeratosis.
References in periodicals archive ?
Keratin 1 (Figure 7(a)) and keratin 10 (Figure 7(b)) gene expression was slightly but not significantly reduced by Vivostat PRF treatment.
Therefore, we analyzed gene expression patterns of early differentiation markers (keratin 1 and keratin 10) and late differentiation markers (transglutaminase-1 and involucrin) in keratinocytes [18-23, 34].
We observed that in vitro treatment of primary keratinocytes with PRGF pronounced late differentiation processes in primary human keratinocytes as documented by a PRGF-mediated decrease of keratin 1 and keratin 10 gene expression paralleled by an increase of transglutaminase-1 and involucrin gene expression.
As keratinocyte differentiation was demonstrated to be EGFR dependent [36-38], we analyzed the influence of the EGFR on the PRGF-mediated alteration of keratin 1, keratin 10, transglutaminase-1, and involucrin gene expression in human keratinocytes by blocking the EGFR via a monoclonal antibody (cetuximab).
Lane, "Monospecific monoclonal antibodies to keratin 1 carboxy terminal (synthetic peptide) and to keratin 10 as markers of epidermal differentiation," The British Journal of Dermatology, vol.
Smart, "C/EBPbeta modulates the early events of keratinocyte differentiation involving growth arrest and keratin 1 and keratin 10 expression," Molecular and Cellular Biology, vol.
PRGF stimulation of primary keratinocytes over 24 hours caused a dose-dependent decrease of keratin 1 (a) and keratin 10 (b) gene expression paralleled by a dose-dependent increase of transglutaminase-1 (c) and involucrin (d) gene expression (real-time PCR analysis, * P <0.05, ** P <0.01, *** P < 0.001, ns = not significant, one-way ANOVA with Tukey's multiple comparison test).
PRGF stimulation (1:10) of primary keratinocytes caused a time-dependent decrease of keratin 1 (a) and keratin 10 (b) gene expression paralleled by a time-dependent increase of transglutaminase-1 (c) and involucrin (d) gene expression.
Analyzing the capacity of PRGF from 14 different donors (PRGF number 1-PRGF number 14), we observed a strong and interindividually different effect of the used PRGF on the expression of keratin 1, keratin 10, transglutaminase-1, and involucrin in primary keratinocytes (a, c, e, g).
Caption: Figure 4: The epidermal growth factor receptor (EGFR) partially mediated the keratin 1, keratin 10, transglutaminase-1, and involucrin gene expression in keratinocytes stimulated with PRGF.