keratan sulfate

(redirected from Keratan sulphate)

keratan sulfate

 [ker´ah-tan]
either of two sulfated mucopolysaccharides (I and II). Keratan sulfate is an important component of the proteoglycan of cartilage, and occurs in the cornea and the nucleus pulposus, and is also an accumulation product in Morquio's syndrome.

ker·a·tan sul·fate

(ker'ă-tan sŭl'fāt),
A type of sulfated mucopolysaccharide containing d-galactose in place of the uronic acid of hyaluronic acid or chondroitin; also containing unsulfated and 6-sulfated N-acetyl-d-glucosamine; found in cartilage, bone, connective tissue, the cornea, aorta, and in the intervertebral disks; accumulates in Morquio syndrome; keratan sulfate I is abundant in cornea and is attached to a protein via an asparaginyl residue; keratan sulfate II is found in loose connective tissue and bone and is linked to a seryl or threonyl residue.
Synonym(s): keratosulfate

keratan sulfate

(kĕr′ə-tăn′)
n.
Any of several glycosaminoglycans found especially in the cornea, cartilage, and bone.

ker·a·tan sul·fate

(ker'ă-tan sŭl'fāt)
A type of sulfated mucopolysaccharide found in cartilage, bone, connective tissue, the cornea, aortae, and in the intervertebral discs; accumulates in Morquio syndrome.
Synonym(s): keratosulfate.
References in periodicals archive ?
Caterson, "Role of keratan sulphate (sulphated poly-N-acetyllactosamine repeats) in keratoconic cornea, histochemical, and ultrastructural analysis," Graefe's Archive for Clinical and Experimental Ophthalmology, vol.
Harper, "Morquio Brailsford disease: a report of four affected sisters with absence of excessive keratan sulphate in the urine," British Journal of Radiology, vol.
The major classes of GAG include hyaluronic acid (HA), heparin sulphate, heparin, chondroitin 4-sulphate, chondroitin 6-sulphate, dermatan sulphate and keratan sulphate.[sup.9]
(1) (2) They both recognised the occurrence of corneal clouding, aortic valve disease and urinary excretion of keratan sulphate. Morquio observed the disorder in 4 siblings in a family of Swedish extraction.