Kawasaki disease

(redirected from Kawasaki's)
Also found in: Dictionary, Thesaurus.
Related to Kawasaki's: Kawasaki's disease

mucocutaneous

 [mu″ko-ku-ta´ne-us]
pertaining to mucous membrane and skin.
mucocutaneous lymph node syndrome Kawasaki's disease.

mu·co·cu·ta·ne·ous lymph node syn·drome

a systemic vasculitis of unknown origin that occurs primarily in children under 8 years of age. Symptoms include a fever lasting more than 5 days; polymorphic rash; erythematous, dry, cracking lips; conjunctival injection; swelling of the hands and feet; irritability; adenopathy; and a perineal desquamative rash. Approximately 20% of untreated patients may develop coronary artery aneurysms. As the child recovers from the illness, thrombocytosis and peeling of the fingertips occur.

Kawasaki disease

Kawasaki syndrome

An acute idioapathic febrile illness that primarily affects children under age 5, especially males, and has a winter-spring seasonality.

Clinical findings
Fever; cervical lymphadenopathy; palmoplantar and mucosal erythaema and oedema; conjunctivitis; gingivitis; maculoerythematous glove-and-sock rash over the hands and feet, which becomes hard, oedematous and sloughs; aneurysms of small- and medium-sized coronary, occasionally peripheral, arteries, with arteritis. Other findings include conjunctival oedema, upper respiratory tract oedema, pharyngeal injection and truncal lymphadenopathy.
 
Aetiology
Uncertain; various bacteria have been implicated, though none definitively.
 
Lab
Increased ESR, CRP, complement, immunoglobulins.
 
Management
Gammaglobulin in IV bolus, aspirin IV.
 
Prognosis
May cause sudden death; 1–5% die of disease.

Kawasaki syndrome case definition (CDC)
Fever of 5 days’ duration (or fever post-IV immunoglobulin if given before 5th day of fever), and 4 of following 5 signs:
• Rash;     
• Cervical lymphadenopathy (1.5+ cm in diameter);
• Bilateral conjunctival injection;   
• Oral mucosal changes—erythaema, fissuring and xerostomia, “strawberry tongue”;    
• Peripheral extremity changes—e.g., acral erythema or oedema, periungual and/or generalised desquamation, polymorphous exanthematous rash.

Kawasaki disease

Mucocutaneous lymph node syndromeA disease of children < age 5 that often follows a 1-2 wk prodrome Etiology Uncertain; bugs implicated include Proprionibacterium acnes or retroviruses, none definitively Clinical Fever, cervical lymphadenopathy, palmoplantar and mucosal erythema and edema, conjunctivitis, gingivitis, maculoerythematous glove-and-sock rash over the hands and feet which becomes hard, swollen–edematous, and sloughs, aneurysms of small and medium-sized coronary, occasionally peripheral arteries, with arteritis Lab ↑ ESR, CRP, complement, Igs Management Igs in IV bolus, aspirin IV Prognosis Possibly sudden death;
1-5% die of disease
Kawasaki disease*  
1. Fever of > 5 days
.
2. Bilateral ocular conjunctival injection
.
3. One or more changes of oral mucosa, including erythema, fissuring and xerostomia, conjunctival edema, mucosal edema of upper respiratory tract, eg pharyngeal injection, dry, fissured lips and 'strawberry tongue'
.
4. One or more changes of extremities, including acral erythema or edema, periungual and/or generalized desquamation, polymorphous exanthematous rash, truncal and cervical lymphadenopathy  
*CDC definition, requires 4+ of the above
.

Ka·wa·sa·ki dis·ease

, Kawasaki syndrome (kă-wă-sah'kē di-zēz', sin'drōm)
A systemic vasculitis of unknown origin that occurs primarily in children younger than 8 years of age. Symptoms include a fever lasting more than 5 days; polymorphic rash; erythematous, dry, cracking lips; conjunctival injection; swelling of the hands and feet; irritability; adenopathy; and a perineal desquamative rash. Approximately 20% of untreated patients may develop coronary artery aneurysms. Treatment includes oral aspirin at high dosage, immune globulin administered intravenously, and supportive care. As the child recovers from the illness, thrombocytosis and peeling of the fingertips occur.
Synonym(s): mucocutaneous lymph node syndrome.

Kawasaki disease

A world-wide disease of infants and young children that causes fever, swollen lymph nodes, a measles-like rash, red eyes, inflamed tongue, dry cracking lips, peeling skin and, in just under half the cases, local widening (ANEURYSMS) in the CORONARY arteries. These are usually transient but 10% have long-term involvement of the coronaries. No causal agent has been discovered but high doses of immune globulin reduce the risk of coronary artery damage. Aspirin is also effective. Fewer than 1% of affected children die from the disease and most make a complete recovery. The condition was first recognized in 1967 by the Japanese paediatrician Dr Tomisaku, in the port of Kawasaki.

Kawasaki,

Tomisaku, 20th century Japanese pediatrician.
Kawasaki disease - a polymorphous erythematous febrile, sometimes epidemic, disease of unknown etiology occurring in children. Synonym(s): Kawasaki syndrome; mucocutaneous lymph node syndrome
Kawasaki syndrome - Synonym(s): Kawasaki disease
References in periodicals archive ?
The learning continues once the expo floor opens on Friday, with Kawasaki's Digital Marketing exhibit, more than 100 new product demonstrations from exhibitors, daily Lunch & Learn roundtable discussions, and the DX Model Store and Store Room.
Kawasaki hopes this report will serve as a basis for dialog with its stakeholders, drawing out input regarding their expectations and requests for Kawasaki's corporate activities.
We now hypothesize that the pathologic release of interleukin-2 receptor into the blood may explain many of the immune abnormalities seen in Kawasaki's syndrome," Barron says.
The implementation of this new software service coincides with Kawasaki's announcement that the company has engaged UPS to warehouse and ship all of its parts, power products and engines.
While Kawasaki's first case is now 25 and healthy, few children have been followed for any amount of time.
Information about Kawasaki's complete line of powersports products and Kawasaki affiliates can be found on the Internet at www.
The company has more than 35 years of experience servicing retailers, and will use distribution centers in Brantford, Ontario and Calgary, Alberta, Canada to provide direct support to Kawasaki's engines and power products Canadian dealer network.
a leader in advanced yet affordable ASICs, announced today that they have entered into an agreement that adds MIPS-Based(TM) proven cores to Kawasaki's ASIC intellectual property (IP) portfolio.
The ceremony will be held in Kawasaki's fabrication sheds, adjacent to a row of subway cars currently being built for New York City riders, and surrounded by hundreds of company employees who represent the diversity of a work force committed to a single goal: excellence.
Its best-selling Ninja(R) sportbikes, classic Vulcan(TM) cruisers, rugged ATV and Mule(TM) utility vehicles and exclusive JET SKI(R) watercraft form the foundation of Kawasaki's Good Times Company image.
Following the recent debut of Kawasaki's and Suzuki's co-developed 250cc four-stroke motocross model, the two-year-old Alliance between the brands will again be evident as Suzuki introduces two Kawasaki-produced models.
Kawasaki's debt has risen over the past few years, reaching 487 billion yen as of March 2000 and resulting in a total debt to capital ratio of 73%, the agency said.