For example, piperonyl butoxide, isosafrole, kavalactones
, podophyllotoxin, and epipodophyllotoxin are involved in the inhibition of CYP activity (Mathews et al.
supplements have been made from kavalactones
, a kava derivative.
This root extraction contains a number of structurally related compounds that are bioactive and are collectively referred to as kavapyrones or kavalactones
In a 3-week randomized trial, patients with anxiety received 250 mg per day of kavalactones
derived from an aqueous extract of the roots of noble Kava cultivars.
Chewing kava--as done on Tanna--is very effective, as the roots are ground into a fine pulp, allowing as many kavalactones
as possible to be absorbed when drunk.
In May 2001, a previously healthy woman aged 45 years reported the onset of nausea and weakness approximately 8 weeks after beginning use of a kava-containing dietary supplement that listed on the package label, "Kava kava extract (root), standardized to 30% kavalactones
(75 mg), hops (strobiles), German chamomile (flower head), passion flower (flower and fruit), gelatin, and natural vegetable fiber.
Some herbs, like valerian root (50-100 mg, twice a day) and kava (with 60-76 mg of kavalactones
, two to three times a day), enhance the absorption of GABA by acting on your brain's GABA receptors.
This experiment sought to characterize the putative anxiolytic properties of Piper methysticum extract and its six principle kavalactones
in the chick social separation-stress paradigm.
When you buy Kava, make sure it contains at least 70mg of kavalactones
, since clinical studies have shown this is the smallest dose which has proved to be effective.
The studies used 300 to 400 mg of kava extracts a day (they contained 210 to 240 mg of kavalactones
, which many researchers think are kava's active ingredients).
Lebot, who now works at the Centre Technique Forestier Tropical in Madagascar, has found that kava packs its punch via a slew of lipid-like substances known as kavalactones