Mr Blythe who is the head of the American Kava Association said that all Kava entering the United States will need to be cleared by the Food & Drugs Administration (FDA), analysed of its chemical compositions, especially the Kavalactone
level, to ensure that products served to the customers are safe for consumption and meet customer satisfaction.
This was of particular concern given the possibility that kavalactone
preparations obtained via ethanol extraction may contain notable levels of flavokawain B, which has been suggested to be a cause of kava related hepatotoxicity (Zhou 2010).
profile is equivalent to the natural root.
Islanders shun plants with lots of DHM, a kavalactone
that causes nausea.
The chemical analysis of the extract's kavalactone
constituents has been previously published (Clayton et al.
profile equivalent to the natural root.
The physiological properties of kava have been demonstrated to result from the kavalactone
content and the chemotype commonly assessed in plants of the same species with genetically defined phytochemical characteristics (Lebot and Levesque 1996; Lebot et al.
Gastrointestinal side effects such as nausea are a known negative effect from kava and is in part due to the kavalactone
dihydromethysticin (Lebot 2006).
For example, the anti-anxiety effect of kava's underground parts can be obtained from its kavalactone
constituents, of which there are six that are known to occur in substantial concentrations.
Duve (1976) found that the total kavalactone
content is typically highest in the lateral roots and decreases continuously towards the aerial parts of the plants.
complex used for the preparation of the special Altromin pellet batches was a commercial extract (Gehrlicher Pharmazeutische Extrakte, Eurasburg, Germany, batch no.
The purpose of this present study was thus to investigate whether ADH activity is altered by kavalactones
as a means of establishing a possible mechanism of kavalactone
-mediated hepatotoxicity especially if it is consumed with alcohol.