Kaposi, Moritz K.

(redirected from Kaposi sarcoma-associated herpesvirus)

Kaposi, Moritz K.

(ko'po-se)
Hungarian dermatologist, 1837–1902. His original name was Moritz Kohn.

Kaposi disease

Xeroderma pigmentosum.
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KAPOSI'S SARCOMA: on skin

Kaposi sarcoma

Abbreviation: KS
A lymphatic endothelial malignancy, rather than a true sarcoma, composed of multiple red or purple macules, papules, or nodules, that is first apparent on the skin or mucous membranes but may involve the internal organs. Once a rare disease seen primarily in elderly men of Mediterranean, African, or Ashkenazi descent (so-called classic KS), it is the most common cancer related to AIDS. In patients with AIDS, KS is believed to be sexually acquired due to acquisition of human herpesvirus 8. When KS is associated with AIDS, it progresses and disseminates rapidly to multiple skin sites, as well as the lymph nodes and visceral organs. See: illustration; AIDS

Symptoms

The lesions are typically painless but may be cosmetically disfiguring or may interfere with internal organ function. They are found most often on the dorsa of the feet and lower extremities in patients with classic KS, and on the face, trunk, oral cavity, and internal organs in immunosuppressed patients. KS is sometimes referred to as “epidemic” in patients with HIV infection; “endemic” in parts of Africa; and “acquired” in patients taking immune-suppressing drugs after organ transplantation. In advanced disease, the lesions may merge into large plaques, sometimes blocking lymphatics and causing localized edema. Involvement of internal organs, primarily the gastrointestinal tract or the lungs, may result in dyspepsia or dyspnea.

Diagnosis

Characteristic tumors on the skin suggest the diagnosis, which should be confirmed by tissue biopsy.

Treatment

Treatment options include radiation therapy, cancer chemotherapies, cryotherapy, hormone therapies, and biotherapy (interferon alfa-2b).

Patient care

Epidemic KS may profoundly alter the patient's appearance. Emotional support for the patient and family may help them cope with the diagnosis and its effects on body image. Psychological counseling may be needed. Standard precautions should be followed when assessing or caring for the patient. The skin should be assessed for new lesions at each health care contact.

Kaposi sarcoma–associated herpesvirus

Abbreviation: KSHV
Human herpesvirus 8.

Kaposi sarcoma herpesvirus

Human herpesvirus 8.

Kaposi varicelliform eruption

Eczema herpeticum.
Medical Dictionary, © 2009 Farlex and Partners
References in periodicals archive ?
Kaposi sarcoma is a multicentric tumor caused by Kaposi sarcoma-associated herpesvirus, also called human herpesvirus-8.
First time detected in Kaposi sarcomas associated with AIDS, this virus was coined Kaposi sarcoma-associated herpesvirus (KSHV), also known as human herpesvirus 8 (HHV-8) [27].
While the causative agent of AIDS was determined in 1984, it was not until a decade later that the viral etiology of KS, the Kaposi sarcoma-associated herpesvirus (KSHV; or HHV-8)) was identified.
Kaposi sarcoma-associated herpesvirus (KSHV) seroprevalence in population-based samples of African children: evidence for at least 2 patterns of KSHV transmission.
The researchers hypothesized that a secondary viral infection could trigger Kaposi sarcoma-associated herpesvirus (KSHV).
(1) Nonstandard abbreviations: HSV, herpes simplex virus; VZV, varicella zoster virus; EBV, Epstein-Barr virus; HHV, human herpesvirus; KSHV, Kaposi sarcoma-associated herpesvirus; ICS, internal calibration standard; PTLD, posttransplant lymphoproliferative disorder.
Lymphatic reprogramming of blood vascular endothelium by Kaposi sarcoma-associated herpesvirus. Nat Genet.
As illustrated by articles in this issue about adiaspiromycosis (2), malaria (3,4), dengue (4), Chagas disease (5), Kaposi sarcoma-associated herpesvirus (6), suspected Brazilian purpuric fever (7), and other infections, new diseases continue to emerge and old ones continue to undergo epidemiologic change throughout the vast Amazon River basin.
Kaposi sarcoma-associated herpesvirus (KSHV) is the cause of Kaposi sarcoma (KS) and certain lymphoproliferative diseases (1).
Kaposi sarcoma-associated herpesvirus encodes a number of homologues to cellular genes that provide proliferative and antiapoptotic signals.
The presence of malaria, dengue fever, orally transmitted Chagas disease, Kaposi sarcoma-associated herpesvirus infection, adiaspiromycosis, and many other emerging diseases indicates that emergence and epidemiologic change are vigorous and ongoing in the Amazon Basin.
These 3 groups of researchers used the same primers as those used to detect Kaposi sarcoma-associated herpesvirus in patients with human immunodeficiency virus infection.