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an angiotensin-converting enzyme inhibitor used, usually with a diuretic, for treatment of hypertension or congestive heart failure in patients who have failed to respond to or developed unacceptable side effects with multiple drug regimens that usually include an adrenergic blocking agent, diuretic, and vasodilator. The most serious adverse reactions associated with its use include proteinuria, neutropenia, and agranulocytosis.
Miller-Keane Encyclopedia and Dictionary of Medicine, Nursing, and Allied Health, Seventh Edition. © 2003 by Saunders, an imprint of Elsevier, Inc. All rights reserved.


Acepril (UK), Apo-Capto (CA), Dom-Captopril, Gen-Captopril (CA), Med-Captopril

Pharmacologic class: Angiotensin-converting enzyme (ACE) inhibitor

Therapeutic class: Antihypertensive

Pregnancy risk category C (first trimester), D (second and third trimesters)

FDA Box Warning

• When used during second or third trimester of pregnancy, drug may cause fetal injury and death. Discontinue as soon as possible when pregnancy is detected.


Prevents conversion of angiotensin I to angiotensin II, which leads to decreased vasoconstriction and, ultimately, to lower blood pressure. Also decreases blood pressure by increasing plasma renin secretion from kidney and reducing aldosterone secretion from adrenal cortex. Decreased aldosterone secretion prevents sodium and water retention.


Tablets: 12.5 mg, 25 mg, 50 mg, 100 mg

Indications and dosages


Adults: 12.5 to 25 mg P.O. two to three times daily; may be increased up to 150/mg/day at 1- to 2-week intervals. Usual dosage is 50 mg t.i.d. If patient is receiving diuretics, start with 6.25 to 12.5 mg P.O. two to three times daily. If blood pressure isn't adequately controlled after 1 to 2 weeks, add diuretic, as prescribed. If further blood pressure decrease is needed, dosage may be raised to 150 mg P.O. t.i.d. while patient continues on diuretic. Maximum dosage is 450 mg/day.

Heart failure

Adults: Usual initial dosage is 25 mg P.O. t.i.d. After increasing to 50 mg P.O. t.i.d. (if indicated), do not increase dosage further for 2 weeks, to determine satisfactory response. Don't exceed 450 mg/day.

Left ventricular dysfunction after myocardial infarction

Adults: 6.25 mg P.O. as a test dose, followed by 12.5 mg t.i.d. May increase up to 50 mg t.i.d.

Diabetic nephropathy

Adults: 25 mg P.O. t.i.d.

Dosage adjustment

• Renal impairment

Off-label uses

• Bartter's syndrome

• Hypertension associated with scleroderma

• Management of hypertensive crisis

• Raynaud's syndrome

• Rheumatoid arthritis

• Severe childhood hypertension


• Hypersensitivity to drug or other ACE inhibitors

• Angioedema (hereditary or idiopathic)

• Pregnancy


Use cautiously in:

• renal or hepatic impairment, hypovolemia, hyponatremia, aortic stenosis and hypertrophic cardiomyopathy, cardiac or cerebrovascular insufficiency, systemic lupus erythematous

• family history of angioedema

• black patients with hypertension

• elderly patients

• breastfeeding patients

• children.


• Discontinue other antihypertensives 1 week before starting captopril, if possible.

• Give 1 hour before meals on empty stomach.

Adverse reactions

CNS: headache, dizziness, drowsiness, fatigue, weakness, insomnia

CV: angina pectoris, tachycardia, hypotension

EENT: sinusitis

GI: nausea, diarrhea, anorexia

GU: proteinuria, erectile dysfunction, decreased libido, gynecomastia, renal failure

Hematologic: anemia, agranulocytosis, leukopenia, pancytopenia, thrombocytopenia

Metabolic: hyperkalemia

Respiratory: cough, asthma, bronchitis, dyspnea, eosinophilic pneumonitis

Skin: rash, angioedema

Other: altered taste, fever


Drug-drug. Allopurinol: increased risk of hypersensitivity reaction

Antacids: decreased captopril absorption Antihypertensives, general anesthetics that lower blood pressure, nitrates, phenothiazines: additive hypotension

Cyclosporine: hyperkalemia

Digoxin, lithium: increased blood levels of these drugs, increased risk of toxicity

Epoetin alfa: additive hyperkalemia

Indomethacin: reduced antihypertensive effect of captopril

Nonsteroidal anti-inflammatory drugs: decreased antihypertensive response

Potassium-sparing diuretics, potassium supplements: hyperkalemia

Probenecid: decreased elimination and increased blood level of captopril

Drug-diagnostic tests. Alanine aminotransferase, alkaline phosphatase, aspartate aminotransferase, bilirubin, blood urea nitrogen, creatinine, potassium: increased levels

Granulocytes, hemoglobin, platelets, red blood cells, sodium, white blood cells: decreased levels

Urine acetone: false-positive result

Drug-food. Any food: decreased captopril absorption

Salt substitutes containing potassium: hyperkalemia

Drug-herbs. Capsaicin, yohimbine: cough

Drug-behaviors. Acute alcohol ingestion: additive hypotension

Patient monitoring

Monitor for sudden blood pressure drop within 3 hours of initial dose if patient is receiving concurrent diuretics and on a low-sodium diet.

• Monitor hematologic, kidney, and liver function test results.

• Check for proteinuria monthly and after first 9 months of therapy.

Patient teaching

• Tell patient to take drug 1 hour before meals on empty stomach.

• Advise patient to report fever, rash, sore throat, mouth sores, fast or irregular heartbeat, chest pain, or cough.

• Inform patient that dizziness, fainting, and light-headedness usually disappear once his body adjusts to drug.

• Tell patient his ability to taste may decrease during first 2 to 3 months of therapy.

• Caution patient to avoid over-the-counter medications unless approved by prescriber.

• As appropriate, review all other significant and life-threatening adverse reactions and interactions, especially those related to the drugs, tests, foods, herbs, and behaviors mentioned above.

McGraw-Hill Nurse's Drug Handbook, 7th Ed. Copyright © 2013 by The McGraw-Hill Companies, Inc. All rights reserved


An ACE inhibitor drug used in the treatment of hypertension, congestive heart failure, and other cardiovascular disorders.
The American Heritage® Medical Dictionary Copyright © 2007, 2004 by Houghton Mifflin Company. Published by Houghton Mifflin Company. All rights reserved.


Capoten® Cardiology A short-acting ACE inhibitor used for HTN, in type 1 DM, heart failure, and post-MI Pts with left ventricular dysfunction; long-term administration of captopril is associated with ↑ survival, and ↓ cardiovascular M&M, possibly attenuating ventricular dilatation and remodeling Warning Angioedema of upper airways Adverse effects Neutropenia, agranulocytosis, proteinuria, rash, pruritus, hypotension, dysgeusia. See ACE inhibitor.
McGraw-Hill Concise Dictionary of Modern Medicine. © 2002 by The McGraw-Hill Companies, Inc.


An angiotensin converting enzyme inhibitor (ACE INHIBITOR) drug used in the treatment of HEART FAILURE and high blood pressure (HYPERTENSION). The drug is on the WHO official list. Brand names are Acepril and Capoten and, with the addition of a thiazide DIURETIC drug, Acezide, Capozide.
Collins Dictionary of Medicine © Robert M. Youngson 2004, 2005
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Kaplon's letter may have been somewhat hastily written, in that he seems to have missed the point that Borenstein was criticizing information presented in a Newstrack item, which reported the discovery of a new prime number.
[8.] DeVan AE, Eskurza I, Pierce GL, Walker AE, Jablonski KL, Kaplon RE, et al.
The following is her story as told to Art Business News editor Megan Kaplon.
The ECC was first developed and used by Kaplon to study heavy primaries in cosmic-ray interactions [7].
Somewhat higher estimates of maternal heritability were computed for NBA and NPW in Polish Large White (0.03 to 0.10; Kaplon et al., 1991) and Canadian Landrace and Yorkshire (0.04 [+ or -] 0.04 to 0.08 [+ or -] 0.04; Southwood and Kennedy, 1990), and for LWW in Czech Landrace and Large White (0.05; Adamec and Johnson, 1997).
and Kaplon, J.: 2002, Dobromierz Geodynamic Network as a Part of GEOSUD Network - Preliminary Analysis of 2001 Measurements, , Acta Montana, Ser.
(4.) Kaplon RJ, Michler RE, Xu H, Kwiatkowski PA, Edwards NM, Platt JL.
Wielgosz, P., Krukowska, M., Paziewski, J., Krypiak-Gregorczyk, A., Stepniak, K., Kaplon, J., Sierny, J., Hadas, T.
Also in this issue of Art Business News, Lance Evans explores how the art industry has transitioned over time--and not without resistance--into the digital realm (page 52), and Megan Kaplon showcases some of spring 2015's special exhibits taking place in museums and galleries across the eastern United States (page 38).
and Kaplon, J.: 2002, Dobromierz geodynamic network as a part of GEOSUD network--preliminary analisys of 2001 measurements, Acta Montana, Ser.
and Fore-Sudetic block (Cacon et al., 2004, 2010; Kaplon and Cacon, 2009; Kaplon et al., 2014; Kontny, 2003; Schenk et al., 2003).
(10.) Bon F, Ambert-Balay K, Giraudon H, Kaplon J, Le Guyader S, Pommepuy M, et al.