Kallmann's syndrome

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Kallmann's syndrome1

Etymology: Franz J. Kallmann, American psychiatrist, 1897-1965
a condition characterized by the absence of the sense of smell and longer-than-average limbs. It is caused by agenesis of the olfactory bulbs and secondary hypogonadism related to a decrease of luteinizing hormone-releasing hormone (interstitial cell-stimulating hormone).

Kallmann's syndrome2

a type of hypogonadotropic hypogonadism caused by failure of fetal gonadotropin-releasing hormone neurons to migrate to the thalamus, usually associated with anosmia or hyposmia. It is usually passed by autosomal-recessive inheritance and, in some cases, is X-linked.

Kallmann's syndrome

Absence of the sense of smell associated with a deficiency of the hormone from the HYPOTHALAMUS that prompts the PITUITARY GLAND to secrete a sex gland stimulating hormone (gonadotrophic releasing hormone). (Franz Josef Kallman, 1897–1965, German-born American geneticist and psychiatrist).
References in periodicals archive ?
If Akhenaten's disorder was indeed partly Kallmann's syndrome (as we suggest), he almost certainly also lacked a sense of smell and, as he aged, possibly developed loss of hearing, blindness and odd neurological defects.
Kallmann's Syndrome, a rare disease that prevents puberty, assured his signature high voice would remain unchanged, but also apparently led to booze-swilling, gun-toting over-assertions of masculinity.
DISCUSSION: Kallmann's syndrome is a condition that specifies hypogonadotrophic hypogonadism and anosmia.