Kallmann syndrome

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Kallmann syndrome

a type of hypogonadotropic hypogonadism caused by failure of fetal gonadotropin-releasing hormone neurons to migrate to the thalamus, usually associated with anosmia or hyposmia. It is usually passed by autosomal recessive inheritance, and some cases are x-linked.
Miller-Keane Encyclopedia and Dictionary of Medicine, Nursing, and Allied Health, Seventh Edition. © 2003 by Saunders, an imprint of Elsevier, Inc. All rights reserved.

hy·po·go·nad·ism with an·os·mi·a

failure of sexual development secondary to inadequate secretion of pituitary gonadotrophins, associated with anosmia due to agenesis of the olfactory lobes of the brain. Autosomal dominant [MIM*147950], autosomal recessive [MIM*244200], and X-linked recessive [MIM*308700] forms exist; the X-linked form is caused by mutation in the Kallmann gene (KAL1) on Xp.
Synonym(s): Kallmann syndrome
Farlex Partner Medical Dictionary © Farlex 2012

Kallmann syndrome

Hypogonadotropic hypogonadism A condition with a highly variable hereditary pattern, characterized by 2º hypogonadism Clinical Delayed puberty, micropenis, eunuchoid features, cryptorchidism, cleft lip and palate, unilateral renal agenesis, horseshoe kidney, nerve deafness and hearing loss, color blindness, skeletal defects; synkinesia, spatial attention defects, spastic paraplegia, cerebellar dysfunction, horizontal nystagmus, pes cavus, mental retardation Management Androgens; gonadotropins or LHRH for spermatogenesis. See Kalig-1.
McGraw-Hill Concise Dictionary of Modern Medicine. © 2002 by The McGraw-Hill Companies, Inc.


Franz Josef, U.S. medical geneticist and psychiatrist, 1897-1965.
Kallmann syndrome - Synonym(s): hypogonadism with anosmia
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