kallikrein

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Related to Kallikreins: Tissue kallikreins

kallikrein

 [kal″ĭ-kre´in]
any of several serine endopeptidases that cleave kininogens to form kinins.
plasma kallikrein a hydrolytic enzyme of the plasma that cleaves HMW (high-molecular-weight) kininogen to produce bradykinin. It also activates several blood coagulation factors and plasminogen. It is formed from prekallikrein by activated coagulation factor XII.
tissue kallikrein a hydrolytic enzyme that cleaves LMW kininogen to produce kallidin. It and closely related forms are found in tissues and various glandular secretions such as lymph, pancreatic juice, urine, and saliva.

kal·li·kre·in

(kal'i-krē'in),
A group of enzymes (for example, plasma, tissue, pancreatic, urinary, or submandibular kallikrein) that converts kininogen by proteolysis to bradykinin or kallidin. Trypsin and plasmin can also effect the conversion. Plasma kallikrein activates factor XII and acts on kininogen. Tissue kallikrein is a serine endopeptidase that can generate kallidin from kininogen.

KLK4

A gene on chromosome 19q13.41 that encodes a serine protease expressed in the prostate.

Molecular pathology
Mutations of KLK4 cause amelogenesis imperfecta hypomaturation type 2A1.

kal·li·kre·in

(kal'i-krē'in)
A group of enzymes (e.g., plasma, tissue, pancreatic, urinary, submandibular kallikrein) that can convert kininogen by proteolysis to bradykinin or kallidin; trypsin and plasmin can also effect the conversion; plasma kallikrein activates the Hageman factor and acts on kininogen. Tissue kallikrein is a serine endopeptidase that can generate kallidin from kininogen.
Synonym(s): kininogenase, kininogenin.

Kallikrein

Any of a group of compounds in the body known as serine endopeptidases that help to break down proteins into smaller units. Prostate-specific antigen belongs to this group of chemicals. A recently discovered kallikrein may be useful as a biomarker for ovarian cancer.
Mentioned in: Ovarian Cancer

kal·li·kre·in

(kal'i-krē'in)
A group of enzymes that can convert kininogen by proteolysis to bradykinin or kallidin.
References in periodicals archive ?
Kallikreins and kininogens in saliva and plasma of patients presenting with rheumatoid arthritis.
However, some detailed information about delayed kallikrein treatment has not been explored, such as, whether different time point treatments after ischemia will cause efficacy difference and if so, which time point for the delayed kallikrein treatment will produce better protection.
Huppe et al., "Kallikreins 5, 6 and 10 differentially alter pathophysiology and overall survival in an ovarian cancer xenograft model," PloS ONE, vol.
In the future, the research will be directed toward elucidating the kallikrein role in cancer progression.
PSA and hK2 are members of the kallikrein gene family (3), and their expression is regulated by the ligand-dependent activation of the androgen receptor.
PSA is encoded by KLK3 [8] (kallikrein-related peptidase 3), a member of a family of 15 kallikrein genes located on human chromosome 19 (4).
Transcriptional upregulation of human tissue kallikrein 6 in ovarian cancer: clinical and mechanistic aspects.
Potential scope of action of tissue kallikreins in CNS immune-mediated disease.
Two kallikreins (hK5 and hK6) were present at lower concentrations in CaP, whereas hK11 was present at increased concentrations.
To compare prostate-specific kallikreins in blood for the differentiation of favorable from unfavorable PCa, we assessed free and total PSA (tPSA), total hK2 (thK2), and free hK2 (thK2) in a large series of 867 patients treated with radical prostatectomy for clinically localized PCa.