kallikrein

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Related to Kallikreins: Tissue kallikreins

kallikrein

 [kal″ĭ-kre´in]
any of several serine endopeptidases that cleave kininogens to form kinins.
plasma kallikrein a hydrolytic enzyme of the plasma that cleaves HMW (high-molecular-weight) kininogen to produce bradykinin. It also activates several blood coagulation factors and plasminogen. It is formed from prekallikrein by activated coagulation factor XII.
tissue kallikrein a hydrolytic enzyme that cleaves LMW kininogen to produce kallidin. It and closely related forms are found in tissues and various glandular secretions such as lymph, pancreatic juice, urine, and saliva.

kal·li·kre·in

(kal'i-krē'in),
A group of enzymes (for example, plasma, tissue, pancreatic, urinary, or submandibular kallikrein) that converts kininogen by proteolysis to bradykinin or kallidin. Trypsin and plasmin can also effect the conversion. Plasma kallikrein activates factor XII and acts on kininogen. Tissue kallikrein is a serine endopeptidase that can generate kallidin from kininogen.

kallikrein

/kal·li·kre·in/ (kal″ĭ-kre´in) any of several serine proteinases that cleave kininogens to form kinins.
plasma kallikrein  a plasma hydrolase that cleaves HMW kininogen to produce bradykinin and also activates blood coagulation factors XII and VII and plasminogen.
tissue kallikrein  a hydrolase of tissues and various glandular secretions that cleaves LMW kininogen to form kallidin.

KLK4

A gene on chromosome 19q13.41 that encodes a serine protease expressed in the prostate.

Molecular pathology
Mutations of KLK4 cause amelogenesis imperfecta hypomaturation type 2A1.

kal·li·kre·in

(kal'i-krē'in)
A group of enzymes (e.g., plasma, tissue, pancreatic, urinary, submandibular kallikrein) that can convert kininogen by proteolysis to bradykinin or kallidin; trypsin and plasmin can also effect the conversion; plasma kallikrein activates the Hageman factor and acts on kininogen. Tissue kallikrein is a serine endopeptidase that can generate kallidin from kininogen.
Synonym(s): kininogenase, kininogenin.

Kallikrein

Any of a group of compounds in the body known as serine endopeptidases that help to break down proteins into smaller units. Prostate-specific antigen belongs to this group of chemicals. A recently discovered kallikrein may be useful as a biomarker for ovarian cancer.
Mentioned in: Ovarian Cancer

kal·li·kre·in

(kal'i-krē'in)
A group of enzymes that can convert kininogen by proteolysis to bradykinin or kallidin.

kallikrein

(kal´ikrē´in),
n a group of enzymes (plasma, tissue, pancreatic, urinary, submandibular kallikrein) that can convert kininogen to bradykinin or kallidin; trypsin and plasmin can also affect the conversion.
kallikrein-kinin system,
n a proposed hormonal system that functions within the kidney, with the en-zyme kallikrein in the re-nal cortex mediating production of bradykinin, which acts as a vasodilator peptide.

kallikrein

any of a group of proteolytic enzymes present in various glands, lymph, urine, blood plasma, etc., or produced directly from mast cells or basophils, or indirectly from activated platelets. The major action of kallikreins is the liberation of kinins from α-2-globulins (kininogens), and they hence have vasodilator and whealing actions.

kallikrein-kinin system
the enzyme system responsible for capillary permeability and smooth muscle contraction.
References in periodicals archive ?
In the future, the research will be directed toward elucidating the kallikrein role in cancer progression.
On May 18, 2005, subsequent to the end of the third quarter, IBEX provided an update on preliminary results from the first in vivo study of its kallikrein program in ovarian cancer.
Further evidence has shown that human tissue kallikrein 7 (KLK7) [6] mRNA is significantly up-regulated in ovarian tumors (20, 21).
Based on these results IBEX plans to conduct further pre-clinical work relative to the most promising of the kallikreins.
Recently developed specific ELISA-type assays of most other kallikreins provided the opportunity to extend our observations on the in vivo hormonal regulation of hK2 and hK3 to other kallikreins.
Increased research and development expenses in fiscal 2005 resulted primarily from expanded activities related to the Company's kallikrein program.
As outlined above, most kallikreins appear to be under sex steroid hormonal regulation.
IBEX believes this high profile publication demonstrates the growing awareness in the scientific community of the role kallikreins may play in cancer-related processes, and that it further validates the Company's research program exploring the role of kallikreins in metastatic disease.
E[acute accent]"Taking into account a growing body of research on kallikreins, Nature Reviews Cancer paper further highlights the expanding role that kallikreins may play in the progression of cancer," said Paul Baehr, President and CEO of IBEX Technologies Inc.
30) found no overexpression of the 15 tissue kallikreins in breast cancer tissue compared with healthy breast tissue and down-regulation of the expression of at least 4 tissue kallikrein genes (KLK5, KLK6, KLK8, and KLK10) in breast cancer tissue.
IBEX has also entered into an agreement with a major diagnostic company to evaluate IBEX's kallikreins with their proprietary sample bank.
Assay conditions, including cross-reactivity to all other kallikreins, recovery, within- and between-run imprecision, and detection limit, were determined similarly to earlier protocols (21).